| CAS NO: | 199854-00-7 |
| 包装 | 价格(元) |
| 5mg | 电议 |
| 10mg | 电议 |
| 50mg | 电议 |
| Physical Appearance | A crystalline solid |
| Storage | Store at -20°C |
| M.Wt | 195.2 |
| Cas No. | 199854-00-7 |
| Formula | C9H9NO4 |
| Synonyms | AcSHA,O-ASHA |
| Solubility | ≤25mg/ml in ethanol;50mg/ml in DMSO;30mg/ml in dimethyl formamide |
| Chemical Name | N-(acetyloxy)-2-hydroxy benzamide |
| Canonical SMILES | CC(=O)ONC(=O)c1ccccc1O |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
O-Acetyl Salicylhydroxamic Acid (O-ASHA) is an irreversible, non-selective inhibitor of COX-1 and COX-2 [1].
Cyclooxygenase (COX) is the key enzyme required for the conversion of arachidonic acid to prostaglandins. Cyclooxygenase enzymes have been involved in diverse physiological situations and disease processes ranging from inflammation to cancer. Until now, two cyclooxygenase isoforms have been identified, COX-1 and COX-2. The COX-1 enzyme is produced constitutively (i.e., gastric mucosa) and COX-2 is inducible (i.e., sites of inflammation) [2].
O-Acetyl Salicylhydroxamic Acid (O-ASHA) inhibited the activity of ovine COX-1 in a time-dependent and irreversible manner with a 50% B/B0 value of approximately 4.5 mM [1]. O-Acetyl Salicylhydroxamic Acid was a novel acetylating agent. O-Acetyl Salicylhydroxamic Acid inhibited PGE2 synthesis in vivo and blocked the cyclooxygenase activity of PGHS in vitro. O-Acetyl Salicylhydroxamic Acid elicited its effects via acetylation of Ser-529 in the cyclooxygenase active site [1].
References:
[1] Loll P J, Sharkey C T, O'Connor S J, et al. O-acetylsalicylhydroxamic acid, a novel acetylating inhibitor of prostaglandin H2 synthase: structural and functional characterization of enzyme-inhibitor interactions[J]. Molecular pharmacology, 2001, 60(6): 1407-1413.
[2] Dubois R N, Abramson S B, Crofford L, et al. Cyclooxygenase in biology and disease[J]. The FASEB journal, 1998, 12(12): 1063-1073.
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