| CAS NO: | 940-69-2 |
| 包装 | 价格(元) |
| 100mg | 电议 |
| 500mg | 电议 |
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 205.34 |
| Cas No. | 940-69-2 |
| Formula | C8H15NOS2 |
| Solubility | insoluble in H2O; ≥23.25 mg/mL in DMSO; ≥6.83 mg/mL in Etoh with ultrasonic |
| Chemical Name | 5-(1,2-dithiolan-3-yl)pentanimidic acid |
| Canonical SMILES | N=C(O)CCCCC1CCSS1 |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
Lipoamide is the neutral amide of α-lipoic acid (LA) [1].
Unlike LA, lipoamide does not occur naturally in either animals or plants. Compared with free LA, lipoamide is a better cofactor for α-oxo-acid dehydrogenase enzymes, and acts as a more efficient antioxidant, with potential therapeutic application in obesity and diabetes [1].
In 3T3-L1 adipocytes, lipoamide (1 ~ 10 μM) increased the number and mitochondrial mass per cell. Lipoamide treatment also increased the copy number of mitochondrial DNA, as well as protein levels and expression of various transcription factors in mitochondrial biogenesis, such as mitochondrial transcription factor A, peroxisome proliferator-activated receptor-γ co-activator-1α, and nuclear respiratory factor 1. In addition, lipoamide (0.1 ~ 100 μM) increased expression of endothelial nitric oxide synthase and formation of cGMP in a dose-dependent manner [1]. In post-ischaemic perfused rat hearts, lipoamide at 0.25 mM increased the lactate utilization. Furthermore, lipoamide activated pyruvate dehydrogenase by 50% in post-ischaemic myocardium [2].
References:
[1]. Shen W, Hao J, Feng Z, et al. Lipoamide or lipoic acid stimulates mitochondrial biogenesis in 3T3-L1 adipocytes via the endothelial NO synthase-cGMP-protein kinase G signalling pathway. British Journal of Pharmacology, 2011, 162(5): 1213-1224.
[2]. Sumegi B, Butwell N B, Malloy C R, et al. Lipoamide influences substrate selection in post-ischaemic perfused rat hearts. Biochemical Journal, 1994, 297: 109-113.
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