Lagosin

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Lagosin

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

6834-98-6

包装与价格：

包装	价格(元)
1mg	电议
5mg	电议

产品介绍

化学性质

Physical Appearance	A solid
Storage	Store at -20°C
M.Wt	670.8
Cas No.	6834-98-6
Formula	C₃₅H₅₈O₁₂
Synonyms	Antibiotic A 246,14-hydroxy Filipin,NSC 105388,NSC 276732
Solubility	Soluble in DMSO
Chemical Name	(3R,4S,6S,8S,10R,12R,14R,15R,16R,17E,19E,21E,23E,25E,27S,28R)-4,6,8,10,12,14,15,16,27-nonahydroxy-3-[(1R)-1-hydroxyhexyl]-17,28-dimethyl-oxacyclooctacosa-17,19,21,23,25-pentaen-2-one
Canonical SMILES	C/C1=C\C=C\C=C\C=C\C=C\[C@H](O)[C@@H](C)OC([C@@]([C@H](O)CCCCC)([H])[C@@H](O)C[C@@H](O)C[C@@H](O)C[C@@H](O)C[C@@H](O)C[C@@H](O)[C@@H](O)[C@@H]1O)=O
运输条件	蓝冰运输或根据您的需求运输。
一般建议	为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。

资料参考

Lagosin, a polyene macrolide antibiotic, has first been extracted from an isolate of a Streptomyces species present in a sample of soil collected in Lagos, Nigeria [1]. It has been reported that the three polyene macrolide antibiotics, fungichromin, lagosin, and cogomycin, showed some stereochemical differences at one or more centers [1].

Lagosin was the most polar member of the filipin family of fungicides with broad spectrum antifungal and antitumor activity, acting via interaction with cell membrane sterols. The antibiotic lagosin, which appeared to be identical to, or a stereoisomer of, fungichromin, and was very similar in structure to the filipins [2]. The equilibrium constants for association of the polyene antibiotics with aqueous suspensions of cholesterol follow the order filipin IIl >amphotericin B >nystatin >lagosin, in agreement with the order reported for the extent of damage these antibiotics cause in natural and model membranes [2].

Reference:
[1] Pandey R C, Guenther E C, AszALos A A, et al. Physicochemical and biological comparison of polyene macrolide antibiotics fungichromin, lagosin and cogomycin[J]. The Journal of antibiotics, 1982, 35(8): 988-996.
[2] Bittman R, Fischkoff S A. Fluorescence studies of the binding of the polyene antibiotics filipin III, amphotericin B, nystatin, and lagosin to cholesterol[J]. Proceedings of the National Academy of Sciences, 1972, 69(12): 3795-3799.