您好，欢迎来到化工原料网！ [登录] [免费注册]
化工原料网
发布求购
位置：首页 > 产品库 > Acetoacetyl Coenzyme A(sodium salt hydrate)
立即咨询
咨询类型：
     
*姓名：
*电话：
*单位：
Email：
*留言内容：
请详细说明您的需求。
*验证码：
 
Acetoacetyl Coenzyme A(sodium salt hydrate)
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Acetoacetyl Coenzyme A(sodium salt hydrate)图片
包装与价格：
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍

Acetoacetyl coenzyme A (acetoacetyl-CoA) is a precursor to HMG-CoA in the isoprenoid pathway.

别名Acetoacetyl-CoA
化学名S-(3-oxobutanoate) coenzyme A, trisodium salt, tetrahydrate
Canonical SMILESO[C@H]1[C@H](N2C=NC3=C2N=CN=C3N)O[C@H](COP(OP(OCC(C)(C)[C@@H](O)C(NCCC(NCCSC(CC(C)=O)=O)=O)=O)([O-])=O)([O-])=O)[C@H]1OP(O)([O-])=O.[Na+].[Na+].[Na+].O.O.O.O
分子式C25H37N7O18P3S•3Na [4H2O]
分子量989.6
溶解度10mg/mL in PBS, pH 7.2
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Acetoacetyl-coenzyme A (acetoacetyl-CoA) is a precursor to HMG-CoA in the isoprenoid pathway.[1],[2] It is reversibly converted to acetyl-CoA by acetoacetyl-CoA thiolase in the mitochondria. Acetoacetyl-CoA thiolase (T2) deficiency results in a build-up of ketone bodies leading to intermittent ketoacidosis.[3],[4] Acetoacetyl-CoA is also an intermediate in the microbial biosynthesis of polyhydroxybutyrate.[5]

References:
[1]. Lynen, F., and Ochoa, S. Enzymes of fatty acid metabolism. Biochem. Biophys. Acta. 12(1-2), 299-314 (1953).
[2]. Miziorko, H.M. Enzymes of the mevalonate pathway of isoprenoid biosynthesis. Arch. Biochem. Biophys. 505(2), 131-143 (2011).
[3]. Daum, R.S., Scriver, C.R., Mamer, O.A., et al. An inherited disorder of isoleucine catabolism causing accumulation of alpha-methylacetoacetate and alpha-methyl-beta -hydroxybutyrate, and intermittent metabolic acidosis. Pediatr. Res. 7(3), 149-160 (1973).
[4]. Fukao, T., Scriver, C.R., and Kondo, N. The clinical phenotype and outcome of mitochondrial acetoacetyl-CoA thiolase deficiency (β-ketothiolase or T2 deficiency) in 26 enzymatically proved and mutation-defined patients. Mol. Genet. Metab. 72(2), 109-114 (2001).
[5]. Jacquel, N., Lo, C.-W., Wei, Y.-H., et al. Isolation and purification of bacterial poly(3-hydroxyalkanoates). Biochem. Eng. J. 39(1), 15-27 (2008).