Cyclosporin D

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Cyclosporin D

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CAS NO:

63775-96-2

包装与价格：

包装	价格(元)
5mg	电议
25mg	电议

产品介绍

化学性质

Physical Appearance	A solid
Storage	Store at -20°C
M.Wt	1214.62
Cas No.	63775-96-2
Formula	C₆₃H₁₁₁N₁₁O₁₂
Solubility	≥60.7 mg/mL in DMSO with gentle warming and ultrasonic; insoluble in H2O; ≥102.6 mg/mL in EtOH
Chemical Name	(3S,6S,9S,12R,13Z,15S,16Z,18S,21S,22Z,24S,30S,31E,33R)-14,17,23,32-tetrahydroxy-6,9,18,24-tetraisobutyl-3,21,30-triisopropyl-1,4,7,10,12,15,19,25,28-nonamethyl-33-((R,E)-2-methylhex-4-enoyl)-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriaconta-13,16,2
Canonical SMILES	C/C([H])=C([H])/C[C@@](C([C@@](N1C)([H])/C(O)=N\[C@@](C(N(CC(N([C@@](/C(O)=N/[C@@](C(N([C@@](/C(O)=N/[C@@](/C(O)=N/[C@](C(N([C@@](C(N([C@@](C(N([C@@](C1=O)([H])C(C)C)C)=O)([H])CC(C)C)C)=O)([H])CC(C)C)C)=O)([H])C)([H])C)([H])CC(C)C)C)=O)([H])C(C)C)([H])CC(
运输条件	蓝冰运输或根据您的需求运输。
一般建议	为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。

资料参考

Cyclosporin D是一种免疫抑制剂[1].

Cyclosporin D(CsD)是一种Cyclosporine A类似物,具有较弱的免疫抑制活性.Cyclosporin D已被用作Cyclosporine A定量的内标物.在人多药耐药卵巢癌细胞中,cyclosporin D显著地克服Adriamycin耐药性[2].在淋巴细胞中,CsD对PHA\PWM以及PMA与Ca2+诱导的细胞增殖具有较弱的抑制作用[3].

在小鼠中,CsD抑制TPA诱导的小鼠耳水肿(98%)以及小鼠皮肤碱性磷酸酶活性(88%).在小鼠胰腺细胞的胞质中,CsD抑制钙离子/钙调蛋白依赖的延伸因子2(EF-2)的磷酸化以及TPA诱导的EF-2增加[1].Cyclosporin D在体外有效抑制恶性疟原虫,口服给予Cyclosporin D在体内可有效抑制伯氏疟原虫发育[4].

参考文献：
[1]. Gschwendt M, Kittstein W, Marks F. The weak immunosuppressant cyclosporine D as well as the immunologically inactive cyclosporine H are potent inhibitors in vivo of phorbol ester TPA-induced biological effects in mouse skin and of Ca2+/calmodulin dependent EF-2 phosphorylation in vitro. Biochem Biophys Res Commun, 1988, 150(2): 545-551.
[2]. Mizuno K, Furuhashi Y, Misawa T, et al. Modulation of multidrug resistance by immunosuppressive agents: cyclosporin analogues, FK506 and mizoribine. Anticancer Res, 1992, 12(1): 21-25.
[3]. Sadeg N, Pham-Huy C, Rucay P, et al. In vitro and in vivo comparative studies on immunosuppressive properties of cyclosporines A, C, D and metabolites M1, M17 and M21. Immunopharmacol Immunotoxicol, 1993, 15(2-3): 163-177.
[4]. Uadia PO1, Ezeamuzie IC, Ladan MJ, et al. Antimalarial activity of cyclosporins A, C and D. Afr J Med Med Sci, 1994, 23(1): 47-51.