| 包装 | 价格(元) |
| 10ug | 电议 |
| 50ug | 电议 |
| 1mg | 电议 |
| Gene ID: | 59067 | Accession #: | Q9HBE4 |
| Alternate Names: | Human IL-21, IL-21, IL21, IL 21, h-IL-21, rh-IL-21, recombinant human IL-21, recombinant IL-21, IL, interluekin. | ||
| Source: | Escherichia Coli. | M.Wt: | 15.5 kDa |
| Appearance: | Lyophilized protein | Storage: | Store at -20°C |
| Formulation: | Lyophilized (from 1 mg/ml solution containing no additives). | ||
| Solubility: | Reconstitute in H2O to a concentration of 0.1-1.0 μg/μl (Note: Gently pippetting to dissolve). The solution can then be diluted into other aqueous buffers and stored at 4℃ for 1 week or -20℃ for future use. | ||
| Shipping Condition: | Gel pack. | Handling: | Centrifuge the vial prior to opening. |
| Usage: | For Research Use Only! Not to be used in humans. | ||
Interleukin-21 (IL-21) is a pleiotropic cytokine produced by CD4+T cells in response to antigenic stimulation. IL-21 induces the differentiation of T-cell-stimulated B-cells into plasma cells and memory B-cells, apoptotic effects in naïve B-cells and stimulated B-cells in the absence of T-cell signaling and stimulates IgG production in conjunction with IL-4. Also, IL-21 enhances the anti-tumor activity of CD8+T-cells and NK cells. The IL21/IL21 R interaction plays important roles in B and T-cell proliferation after antigen stimulation and NK cell maturation.
The human IL-21 cDNA encodes a 155 aa protein with a 22 aa signal sequence. Recombinant human IL-21 is a homodimeric, non-glycosylated polypeptide containing 133 amino acid residues and has a molecular weight of 15.5 kDa.
| Determined by the dose-dependent stimulation of human peripheral blood mononuclear cells. | ||||||
| ED50 | < 5 ng/ml. | |||||
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