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SKF 81297 hydrobromide
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
SKF 81297 hydrobromide图片
CAS NO:67287-39-2
包装与价格：
包装价格(元)
5mg电议
10mg电议
25mg电议

产品介绍

化学性质

Physical AppearanceA crystalline solid
StorageStore at -20°C
M.Wt370.67
Cas No.67287-39-2
FormulaC16H16ClNO2·HBr
SolubilitySoluble in DMSO
Chemical Name(R)-6-chloro-1-phenyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine-7,8-diol hydrobromide
Canonical SMILESClC1=C2C([C@@H](C3=CC=CC=C3)CNCC2)=CC(O)=C1O.Br
运输条件蓝冰运输或根据您的需求运输。
一般建议为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。

资料参考

SKF 81297 hydrobromide is a selective agonist of the dopamine D1-like receptor, with aKivalue of 1.9 nM. The dopamine D1-like receptors, consisting of D1 and D5 subtypes, are a subfamily of dopamine receptors that mediate excitatory neurotransmission after binding the endogenous neurotransmitter dopamine. The dopamine D1-like receptors have been implicated in dopaminergic regulation of a variety of fundamental neurophysiologic processes including mood, motivation, cognitive function, as well as motor activity.

References:

1. Neumeyer JL, Kula NS, Bergman J, Baldessarini RJ. Receptor affinities of dopamine D1 receptor-selective novel phenylbenzazepines. European Journal of Pharmacology, 2003, 474(2-3): 137-140.

2. Undieh AS. Pharmacology of signaling induced by dopamine D(1)-like receptor activation. Pharmacology & Therapeutics, 2010, 128(1): 37-60.

3. Vermeulen RJ, Drukarch B, Sahadat MC, et al. The dopamine D1 agonist SKF 81297 and the dopamine D2 agonist LY 171555 act synergistically to stimulate motor behavior of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned parkinsonian rhesus monkeys. Movement Disorders, 1994, 9(6): 664-672.

试验操作

Animal experiment:[3]

Animal models

1-Methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP)-lesioned parkinsonian rhesus monkeys

Dosage form

0.3 mg/kg

Injected intramuscularly

Applications

Coadministration of behaviorally active doses of the dopamine D1 agonist SKF 81297 (0.3 mg/kg) and the dopamine D2 agonist LY 171555 (0.01 mg/kg) resulted in a prolongation of the motor stimulation induced by either of the drugs alone. Neither administration of SKF 81297, in a dose of 0.03 mg/kg, nor of LY 171555, in a dose of 0.003 mg/kg, were behaviorally active, whereas the combined administration of these compounds induced a significant stimulation of motor behavior.

Note

The technical data provided above is for reference only.

References:

1. Mancini JA, Prasit P, Coppolino MG, et al. 5-Lipoxygenase-activating protein is the target of a novel hybrid of two classes of leukotriene biosynthesis inhibitors. Molecular Pharmacology, 1992, 41(2): 267-272.

2.Dixon RA, Diehl RE, Opas E, et al. Requirement of a 5-lipoxygenase-activating protein for leukotriene synthesis. Nature, 1990, 343(6255): 282-284.

3. Kehrer JP, Biswal SS, La E, et al. Inhibition of peroxisome-proliferator-activated receptor (PPAR)alpha by MK886. Biochemical Journal, 2001, 356(Pt 3): 899-906.

4. Imbesi M, Zavoreo I, Uz T, et al. 5-Lipoxygenase inhibitor MK-886 increases GluR1 phosphorylation in neuronal cultures in vitro and in the mouse cortex in vivo. Brain Research, 2007, 1147: 148-153.