您好,欢迎来到化工原料网! [登录] [免费注册]
化工原料网
位置:首页 > 产品库 > Naltrindole hydrochloride
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
Naltrindole hydrochloride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Naltrindole hydrochloride图片
CAS NO:111469-81-9
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议

产品介绍

化学性质

Physical AppearanceA crystalline solid
StorageStore at RT
M.Wt450.96
Cas No.111469-81-9
FormulaC26H26N2O3·HCl
SolubilitySoluble in DMSO
Chemical Name(4bS,8R,8aR,14bR)-7-(cyclopropylmethyl)-5,6,7,8,8a,9,14,14b-octahydro-4,8-methanobenzofuro[2,3-a]pyrido[4,3-b]carbazole-1,8a-diol hydrochloride
Canonical SMILESO[C@]([C@@H]1N(CC2CC2)CC3)(CC4=C5NC6=CC=CC=C46)[C@@]3(C7=C(C=C8)C1)[C@H]5OC7=C8O.Cl
运输条件蓝冰运输或根据您的需求运输。
一般建议为了使其更好的溶解,请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存,请尽快用完。

资料参考

Naltrindole hydrochloride is a cell permeable, highly selective non-peptide δ opioid antagonist (Ki = 0.02 nM).

In U266 cells, naltrexone treatment can significantly reduce the active phosphorylated form of kinases, and extracellular signaling regulates kinase and Akt levels, which may be related to its anti-proliferative activity[1].

In mice, naltrindole (20 mg/kg, s.c) antagonizes the δ-selective agonist effect of enkephalin (DSLET), but does not prevent the anti-nociceptive effects of morphine or U50488H. Naltrexone is the only highly selective delta antagonist that is active when administered peripherally[2].

References:

[1]. Mundra J J, et al. Naltrindole inhibits human multiple myeloma cell proliferation in vitro and in a murine xenograft model in vivo. J Pharmacol Exp Ther, 2012, 342(2): 273-87.

[2]. Portoghese P S, et al. Naltrindole, a highly selective and potent non-peptide delta opioid receptor antagonist. Eur J Pharmacol, 1988, 146(1): 185-6.