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5-hydroxy Diclofenac
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
5-hydroxy Diclofenac图片
CAS NO:69002-84-2
包装与价格:
包装价格(元)
1mg电议
5mg电议

产品介绍
Cas No.69002-84-2
别名5-羟基双氯芬酸
Canonical SMILESClC1=C(NC2=C(CC(O)=O)C=C(O)C=C2)C(Cl)=CC=C1
分子式C14H11Cl2NO3
分子量312.2
溶解度Soluble in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

5-hydroxy Diclofenac is a metabolite of the NSAID diclofenac formed by the cytochrome P450 (CYP) isoform CYP3A4. Diclofenac is a non-selective COX inhibitor. It inhibits human COX-1 and -2 with IC50 values of 0.9-2.7 and 1.5-20 µM, respectively. Diclofenac inhibits ovine COX-1 and -2 with IC50 values of 60 and 220 nM, respectively.