4-Methylumbelliferyl 2-sulfamino-2-deoxy-α-D-Glucopyranoside（钠盐）是肝素磺胺酶的荧光底物，脱硫成 4-MU-α-GlcNH2。
| Cas No. | 460085-45-4 |
| 别名 | 4-甲基香豆素-2-磺胺-2-去氧基-Α-D-葡糖苷酸钠盐 |
| Canonical SMILES | OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](NS([O-])(=O)=O)[C@@H](OC2=CC=C(C(C)=CC(O3)=O)C3=C2)O1.[Na+] |
| 分子式 | C16H18NO10S•Na |
| 分子量 | 439.4 |
| 溶解度 | DMSO: Slightly Soluble,Water: Slightly Soluble |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | 4-Methylumbelliferyl 2-sulfamino-2-deoxy-α-D-Glucopyranoside (4-MU-α-GlcNS) is a fluorogenic substrate of heparin sulphamidase. Heparin sulphamidase cleaves 4-MU-α-GlcNS to yield 4-MU-α-GlcNH2, which is then cleaved by α-glucosaminidase to release the fluorescent product 4-MU, which displays an emission maxima of 445-454 nm. The excitation maxima for 4-MU is pH-dependent: 330, 370, and 385 nm at pH 4.6, 7.4, and 10.4, respectively. 4-MU-α-GlcNS has been used to quantify heparin sulphamidase deficiencies associated with Mucopolisaccaridosis IIIA and other lysosomal disorders. |
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