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Levomefolate calcium
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Levomefolate calcium图片
CAS NO:151533-22-1
包装与价格:
包装价格(元)
5mg电议
10mg电议

产品介绍
左旋叶酸钙是一种人工形式的叶酸。
Cas No.151533-22-1
别名左旋甲状腺素钙
化学名calcium (S)-4-(4-(((S)-2-amino-5-methyl-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl)(methyl)amino)benzamido)-4-carboxybutanoate 4-(4-(((S)-2-amino-5-methyl-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl)(methyl)amino)benzamido)-4-carboxybutanoate
Canonical SMILESCN1C(CNC2=C1C(=O)N=C(N2)N)CNC3=CC=C(C=C3)C(=O)NC(CCC(=O)O)C(=O)O.[Ca+2]
分子式C40H48CaN14O12
分子量499.53
溶解度<4.73 mg/mL in DMSO,<4.99 mg/mL in Water,<2.4 mg/mL in EtOH
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Levomefolate calcium is an artificial form of folate.IC50 Value:Target: AntifolateThe calcium salt of L-5-methyltetrahydrofolic acid which belongs to the group of folate vitamins (Vitamin B9, Folacin). It is a coenzymated form of folic acid and a more bioavailable alternative in dietary supplements.

References:
[1]. Fruzzetti F. Beyaz : an oral contraceptive fortified with folate. Womens Health (Lond Engl). 2012 Jan;8(1):13-9.
[2]. Wiesinger H, Eydeler U, Richard F, et al. Bioequivalence evaluation of a folate-supplemented oral contraceptive containing ethinylestradiol/drospirenone/levomefolate calcium versus ethinylestradiol/drospirenone and levomefolate calcium alone. Clin Drug Investig. 2012 Oct 1;32(10):673-84.
[3]. Hartmut Blodea, Christine Klippingb, Frank Richardc, et al. Bioequivalence study of an oral contraceptive containing ethinylestradiol/drospirenone/levomefolate calcium relative to ethinylestradiol/drospirenone and to levomefolate calcium alone. Contraception.2012, 85(2), :177-184
[4]. Rapkin RB, Creinin MD. The combined oral contraceptive pill containing drospirenone and ethinyl estradiol plus levomefolate calcium. Expert Opin Pharmacother. 2011 Oct;12(15):2403-10. doi: 10.1517/14656566.2011.610791.
[5]. Levomefolic_acid