β-Apooxytetracycline is a potential impurity found in commercial preparations of oxytetracycline.
| Cas No. | 18751-99-0 |
| 别名 | 载脂蛋白-土霉素 |
| Canonical SMILES | OC1=CC=CC2=C1C(O)=C3C([C@]([C@]4([H])[C@@H](O)C(C(C(N)=O)=C(O)[C@H]4N(C)C)=O)([H])OC3=O)=C2C |
| 分子式 | C22H22N2O8 |
| 分子量 | 442.4 |
| 溶解度 | DMF: 12 mg/ml,DMSO: 20 mg/ml,Ethanol: 5 mg/ml,PBS (pH 7.2): 0.2 mg/ml |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | β-Apooxytetracycline is a potential impurity found in commercial preparations of oxytetracycline. β-Apooxytetracycline is a degradation product formed from oxytetracycline via acid hydrolysis. It has a relative potency of 0.1 compared with oxytetracycline for inhibiting the growth of aerobic sludge bacteria, an MIC50 value of 32 mg/L for tetracycline-sensitive strains of Pseudomonas, and MIC50 values of greater than 32 mg/L for tetracycline-sensitive strains of Agrobacterium, Moraxella, and Bacillus, as well as tetracycline-resistant strains of E. coli. β-Apooxytetracycline (10 mg/kg) is toxic to rats, decreasing body weight, disrupting blood cell counts, and inducing hepatocyte necrosis. |
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