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Noradrenaline bitartrate monohydrate
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Noradrenaline bitartrate monohydrate图片
CAS NO:108341-18-0
包装与价格:
包装价格(元)
10mM (in 1mL DMSO)电议
500mg电议
1g电议
5g电议

产品介绍

化学性质

Physical AppearanceA solid
StorageStore at -20°C
M.Wt337.28
Cas No.108341-18-0
FormulaC8H11NO3·C4H6O6·H2O
Solubilityinsoluble in EtOH; ≥11.35 mg/mL in DMSO; ≥51 mg/mL in H2O
Chemical Name4-[(1R)-2-amino-1-hydroxyethyl]benzene-1,2-diol;(2R,3R)-2,3-dihydroxybutanedioic acid;hydrate
Canonical SMILESC1=CC(=C(C=C1C(CN)O)O)O.C(C(C(=O)O)O)(C(=O)O)O.O
运输条件蓝冰运输或根据您的需求运输。
一般建议为了使其更好的溶解,请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存,请尽快用完。

资料参考

Noradrenaline bitartrate monohydrate is an agonist of adrenergic receptors, with Ki values of 330, 56 and 740 nM for α1, α2 and β1 adrenoceptors, respectively [1].

Noradrenaline is a neurotransmitter distributed in both the peripheral and central nervous systems. In the autonomic nervous system, noradrenaline acting at α1-receptors causes constriction of cutaneous blood vessels. In the central nervous system, noradrenaline found primarily in the locus coeruleus in the brainstem, plays important roles in a variety of physiological activities, such as sleep/wake cycles, attention, orientation, mood and memory [2].

In femoral strips isolated from the untreated dogs, noradrenaline bitartrate monohydrate (5 × 10-9 ~ 10-4 M) induced dose-dependent contractions which were inhibited completely by 10-8 M phenoxybcnzamine administered 40 min previously. In the femoral strips isolated from the ephedrine-treated dogs, contractile responses to noradrenaline bitartrate monohydrate were potentiated at low concentrations (5 × 10-9 ~ 10-7 M) but inhibited at high concentrations (5 × 10-7 ~ 10-4 M) [3].

References:

[1]. Ramos B P, Arnsten A F. Adrenergic pharmacology and cognition: focus on the prefrontal cortex. Pharmacology & Therapeutics, 2007, 113(3): 523-536.

[2]. Bylund D B, Bylund K C. Norepinephrine. Encyclopedia of the Neurological Sciences (Second Edition), 2014, 3: 638–640.

[3]. Furukawa T, Morishita H. Modifications of responses to adrenergic drugs in arterial strip by treatment in vivo with ephedrine and reserpine. The Japanese Journal of Pharmacology, 1975, 25(4): 441-451.