Pilocarpine HCl

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Pilocarpine HCl

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

54-71-7

包装与价格：

包装	价格(元)
10mM (in 1mL DMSO)	电议
100mg	电议
500mg	电议

产品介绍

化学性质

Physical Appearance	A solid
Storage	Store at -20°C
M.Wt	244.72
Cas No.	54-71-7
Formula	C₁₁H₁₆N₂O₂·HCl
Solubility	≥101 mg/mL in H2O; ≥18.57 mg/mL in EtOH; ≥8.35 mg/mL in DMSO
Chemical Name	(3S,4R)-3-ethyl-4-((1-methyl-1H-imidazol-5-yl)methyl)dihydrofuran-2(3H)-one hydrochloride
Canonical SMILES	Cl[H].O=C1OC([H])([H])[C@@](C([H])([H])C2=C([H])N=C([H])N2C([H])([H])[H])([H])[C@]1([H])C([H])([H])C([H])([H])[H]
运输条件	蓝冰运输或根据您的需求运输。
一般建议	为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。

资料参考

（Synonyms: Pilocarpine hydrochloride)

Pilocarpine HCl is a nonselective muscarinic acetylcholine receptor agonist used to produce an experimental model of epilepsy, as a medication used to increase pressure inside the eye and dry mouth.

Pilocarpine Hydrochloride is the hydrochloride salt of a natural alkaloid with cholinergic agonist activity,extracted from plants of the genus Pilocarpus.

As a cholinergic parasympathomimetic agent, pilocarpine mainly binds to muscarinic receptors, thereby it can induce exocrine gland secretion and stimulate smooth muscle in the bronchi, urinary tract, intestinal tract, and biliary tract.

When this agent is applied topically to the eye, it stimulates the sphincter pupillae to contract, causing miosis; stimulates the ciliary muscle to contract, producing spasm of accomodation; and due to opening of the trabecular meshwork and increasing in the outflow of aqueous humor. it may cause a transitory rise in intraocular pressure followed by a more persistent fall.

The assay in animal, the Pilocarpine-induced saliva secretion of the control rats (CN) and exercised (EX) rats are examined, a greater amount of saliva is induced by Pilocarpine in the EX rats than in the CN rats (P<0.01). On the contrary, the Na+ concentration in the saliva of the EX rats is much lower than that of the CN rats (P<0.05).

References：

1. Thomas, R.L., Langmead, C.J., Wood, M.D., et al. Contrasting effects of allosteric and orthosteric agonists on M1 muscarinic acetylcholine receptor internalization and down-regulation. J. Pharmacol. Exp. Ther. 331(3), 1086-1095 (2009).

2. Smolders, I., Khan, G.M., Manil, H., et al. NMDA receptor-mediated pilocarpine-induced seizures: Characterization in freely moving rats by microdialysis. Br. J. Pharmacol. 121(6), 1171-1179 (1997).

3. Matsuzaki K, et al. Daily voluntary exercise enhances pilocarpine-induced saliva secretion and aquaporin 1 expression in rat submandibular glands. FEBS Open Bio. 2017 Dec 7;8(1):85-93.