Haloperidol

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Haloperidol

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

52-86-8

包装与价格：

包装	价格(元)
10mM (in 1mL DMSO)	电议
500mg	电议
1g	电议

产品介绍

化学性质

Physical Appearance	A solid
Storage	Store at -20°C
M.Wt	375.86
Cas No.	52-86-8
Formula	C₂₁H₂₃ClFNO₂
Solubility	insoluble in H2O; ≥18.79 mg/mL in DMSO; ≥2.52 mg/mL in EtOH with gentle warming and ultrasonic
Chemical Name	4-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]-1-(4-fluorophenyl)butan-1-one
Canonical SMILES	C1CN(CCC1(C2=CC=C(C=C2)Cl)O)CCCC(=O)C3=CC=C(C=C3)F
运输条件	蓝冰运输或根据您的需求运输。
一般建议	为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。

资料参考

Haloperidol是一种抗精神病药,与抗精神病药吩噻嗪具有相似功能[1].

Haloperidol是一种多巴胺的反相激动剂.此外,Haloperidol也可抑制神经功能,从而缓解紧张,是高度有效的抗精神病药.并且,Haloperidol具有比另一种抗精神病药chiorpromazine强约50倍的效果.Haloperidol在治疗妄想和幻觉方面也有有益的效果.这些功能主要通过阻断大脑皮层和边缘系统中的多巴胺受体达成.Haloperidol可防止黑质纹状体途径中多巴胺的效果,这可能可以解释相关的副作用,如静坐不能和肌张力障碍[1].

参考文献：
[1] Dr Ananya Mandal, MD . Haloperidol Pharmacology.

试验操作

Animal experiment:[1]
Animal models	Male Sprague-Dawley rats, 225 ~ 250 g
Dosage form	0, 0.01, 0.05, 0.1 or 0.5 mg/kg Administered subcutaneously
Applications	In rats, the dopamine agonist apomorphine (APO) caused a significant decrease in prepulse inhibition (PPI) of the acoustic startle response, which could be reversed in a dose-dependent manner by haloperidol. PPI of the acoustic startle response is a measure of sensorimotor gating that is impaired in both schizophrenic patients and in rats treated with dopamine agonists. The ability of antipsychotics such as haloperidol to restore PPI in APO-treated rats correlates significantly with their clinical potency.
Note	The technical data provided above is for reference only.
	References: 1. Swerdlow NR, Geyer MA. Clozapine and haloperidol in an animal model of sensorimotor gating deficits in schizophrenia. Pharmacol Biochem Behav. 1993 Mar;44(3):741-4.