| CAS NO: | 20830-81-3 |
| 包装 | 价格(元) |
| 10mg | 电议 |
| 50mg | 电议 |
| Storage | Store at -20°C |
| M.Wt | 527.52 |
| Cas No. | 20830-81-3 |
| Formula | C27H29NO10 |
| Solubility | ≥83.33 mg/mL in DMSO |
| Chemical Name | (7S,9S)-9-acetyl-7-[(2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyloxan-2-yl]oxy-6,9,11-trihydroxy-4-methoxy-8,10-dihydro-7H-tetracene-5,12-dione |
| Canonical SMILES | CC1C(C(CC(O1)OC2CC(CC3=C(C4=C(C(=C23)O)C(=O)C5=C(C4=O)C=CC=C5OC)O)(C(=O)C)O)N)O |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
Daunorubicin是DNA拓扑异构酶II的抑制剂[1].
Daunorubicin是一种蒽环类抗生素,有效治疗各种肿瘤,特别是急性髓性白血病和急性淋巴细胞性白血病.Daunorubicin可以影响DNA和RNA的代谢与合成.在体外测定中,Daunorubicin抑制胸苷和尿苷进入L1210细胞.Daunorubicin也能抑制标记前体掺入到从培养细胞分离的DNA和RNA中.从急性淋巴细胞性白血病患者中分离白血病细胞,给予Daunorubicin可以显著抑制DNA和RNA大分子的生物合成[2,3].
参考文献：
[1] Hande K R. Etoposide: four decades of development of a topoisomerase II inhibitor. European Journal of Cancer, 1998, 34(10): 1514-1521.
[2] Momparler R L, Karon M, Siegel S E, et al. Effect of adriamycin on DNA, RNA, and protein synthesis in cell-free systems and intact cells. Cancer Research, 1976, 36(8): 2891-2895.
[3] Meriwether W D, Bachur N R. Inhibition of DNA and RNA metabolism by daunorubicin and adriamycin in L1210 mouse leukemia. Cancer research, 1972, 32(6): 1137-1142.
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