| CAS NO: | 179411-93-9 |
| 包装 | 价格(元) |
| 10mg | 电议 |
| 50mg | 电议 |
| Storage | Store at -20°C |
| M.Wt | 406.2 |
| Cas No. | 179411-93-9 |
| Formula | C16H18Cl2NO5P |
| Solubility | Soluble in DMSO |
| Chemical Name | (S)-2-amino-3-(2'-chloro-5-(phosphonomethyl)-[1,1'-biphenyl]-3-yl)propanoic acid hydrochloride |
| Canonical SMILES | ClC1=CC=CC=C1C2=CC(C[C@@](N)([H])C(O)=O)=CC(CP(O)(O)=O)=C2.Cl |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
SDZ 220-581 hydrochloride是有效的NMDA受体竞争性拮抗剂,其pKi值为7.7[1].
SDZ220-581是一种联苯AP7衍生物,在体内外均显效.SDZ 220-581以高亲和力结合到NMDA受体的识别位点,而不会结合NMDA受体的士的宁不敏感甘氨酸位点或MK-801位点.此外,SDZ 220-581对其它各种结合试验没有影响,如多巴胺\血清素和腺苷[1].
在体内试验中,SDZ 220-581保护小鼠免受最大电休克诱发的癫痫(MES).在大鼠MES模型中,SDZ 220-581也显效.此外,在大鼠中,SDZ 220-581可以保护大脑免受喹啉酸诱导的神经元变性.在局灶性脑缺血大鼠模型中,1.25 mg/kg SDZ 220-581显著降低脑梗塞大小[2].
参考文献：
[1] Urwyler et al . Biphenyl-derivatives of 2-amino-7-phosphono-heptanoic acid, a novel class of potent competitive N-methyl-D-aspartate receptor antagonists - II. Pharmacological characterization in vivo. Neuropharmacology 1996, 35 655.
[2] Urwyler S, Campbell E, Fricker G, et al. Biphenyl-derivatives of 2-amino-7-phosphono-heptanoic acid, a novel class of potent competitiveN-Methyl-D-aspartate receptor antagonists—II. Pharmacological characterization in vivo[J]. Neuropharmacology, 1996, 35(6): 655-669.
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