CAS NO: | 501104-16-1 |
包装 | 价格(元) |
1mg | 电议 |
10mg | 电议 |
50mg | 电议 |
Cas No. | 501104-16-1 |
化学名 | 4-morpholinecarboxylic acid, 4-(1-piperidinyl)-1,2,5-thiadiazol-3-yl ester |
Canonical SMILES | O=C(N1CCOCC1)OC2=NSN=C2N3CCCCC3 |
分子式 | C12H18N4O3S |
分子量 | 298.4 |
溶解度 | 20 mg/ml in DMSO, 20 mg/ml in DMF, 20 mg/ml in Ethanol |
储存条件 | Store at -20°C |
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
产品描述 | Lalistat 1 is an inhibitor of lysosomal acid lipase (LAL; IC50 = 68 nM using purified human LAL). [1] It is selective for LAL over human pancreatic and bovine milk lipoprotein lipases up to a concentration of 10 µM.[2] Lalistat 1 (0.01-10 µM) reduces cholesterol accumulation in lysosome-like storage organelles in GM03123 human fibroblast cells deficient in NPC1, a membrane protein found in late endosomes, in a concentration-dependent manner but has little effect on cholesterol accumulation in NPC1-deficient CHO cells. Reference |