您好,欢迎来到化工原料网! [登录] [免费注册]
化工原料网
位置:首页 > 产品库 > Lalistat 1
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
Lalistat 1
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Lalistat 1图片
CAS NO:501104-16-1
包装与价格:
包装价格(元)
1mg电议
10mg电议
50mg电议

产品介绍
Lalistat 1 是一种有效的、选择性的、竞争性的溶酶体酸性脂肪酶 (LAL) 抑制剂和纯化的人 LAL (phLAL),IC50 为 68 nM。
Cas No.501104-16-1
化学名4-morpholinecarboxylic acid, 4-(1-piperidinyl)-1,2,5-thiadiazol-3-yl ester
Canonical SMILESO=C(N1CCOCC1)OC2=NSN=C2N3CCCCC3
分子式C12H18N4O3S
分子量298.4
溶解度20 mg/ml in DMSO, 20 mg/ml in DMF, 20 mg/ml in Ethanol
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Lalistat 1 is an inhibitor of lysosomal acid lipase (LAL; IC50 = 68 nM using purified human LAL). [1] It is selective for LAL over human pancreatic and bovine milk lipoprotein lipases up to a concentration of 10 &#181M.[2] Lalistat 1 (0.01-10 &#181M) reduces cholesterol accumulation in lysosome-like storage organelles in GM03123 human fibroblast cells deficient in NPC1, a membrane protein found in late endosomes, in a concentration-dependent manner but has little effect on cholesterol accumulation in NPC1-deficient CHO cells.

Reference
[1]. Rosenbaum, A.I., Rujoi, M., Huang, A.Y., et al. Chemical screen to reduce sterol accumulation in Niemann-Pick C disease cells identifies novel lysosomal acid lipase inhibitors. Biochim Biophys. Acta. 1791(12), 1155-1165 (2009).
[2]. Rosenbaum, A.I., Cosner, C.C., Mariani, C.J., et al. Thiadiazole carbamates: Potent inhibitors of lysosomal acid lipase and potential Niemann-Pick type C disease therapeutics. J. Med. Chem. 53(14), 5281-5289 (2010).