Formoterol fumarate dihydrate

Molecular Weight (MW)	496.51
Formula	2(C19H24N2O4).C4H4O4.2(H2O)
CAS No.	183814-30-4
Storage	-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)	DMSO: ≥ 50 mg/mL
Water: < 1 mg/mL
Ethanol: NA
Chemical Name	N-[2-Hydroxy-5-[(1R)-1-hydroxy-2-[[(1R)-2-(4-methoxyphenyl)-1-methylethyl]amino]ethyl]phenyl]-formamide
Synonyms	(-)-Formoterol; Arformoterol; (R,R)-Formoterol; Formoterol; arformoterol; (R,R)-Formoterol; BD 40A; eformoterol; Foradil; formoterol fumarate; Trade names: Atock, Atimos/Atimos Modulite, Foradil/Foradile, Oxeze/Oxis, and Perforomist.

Molecular Weight (MW)

496.51

Formula

2(C19H24N2O4).C4H4O4.2(H2O)

CAS No.

183814-30-4

Storage

-20℃ for 3 years in powder form

-80℃ for 2 years in solvent

Solubility (In vitro)

DMSO: ≥ 50 mg/mL

Water: < 1 mg/mL

Ethanol: NA

Chemical Name

N-[2-Hydroxy-5-[(1R)-1-hydroxy-2-[[(1R)-2-(4-methoxyphenyl)-1-methylethyl]amino]ethyl]phenyl]-formamide

Synonyms

(-)-Formoterol; Arformoterol; (R,R)-Formoterol; Formoterol; arformoterol; (R,R)-Formoterol; BD 40A; eformoterol; Foradil; formoterol fumarate; Trade names: Atock, Atimos/Atimos Modulite, Foradil/Foradile, Oxeze/Oxis, and Perforomist.

In Vitro	In vitro activity: Formoterol restored Dex sensitivity by inhibiting phosphorylation of GR-Ser226 and JNK1. Formoterol (FM), but not SM, partially inhibited H(2) O(2) -induced PI3Kδ-dependent (PKB) phosphorylation. H(2) O(2) decreased SM-induced cAMP production in U937 cells, but did not significantly affect the response to FM. Kinase Assay: Formoterol(Arformoterol) is a novel highly β2-selective adrenergic agonist and holds promise as a β2-agonist that could impart selective beneficial metabolic effects. Cell Assay:
In Vivo	Mice exposed to formoterol for 24 or 72 h exhibited increases in kidney and heart mtDNA copy number, peroxisome proliferator-activated receptor γ coactivator 1α, and multiple genes involved in the mitochondrial electron transport chain (F0 subunit 6 of transmembrane F-type ATP synthase, NADH dehydrogenase subunit 1, NADH dehydrogenase subunit 6, and NADH dehydrogenase [ubiquinone] 1β subcomplex subunit 8). Formoterol and ritodrine inhibited the amplitude and frequency of rat uterine contraction, with IC50 values of 3.8 x 10(-10) and 4.7 x 10(-7) M, respectively.
Animal model	Mouse
Formulation & Dosage
References	Am J Respir Cell Mol Biol. 2011 Jul; 45(1): 88–94; BMC Pediatr. 2012 Mar 7;12:21.

In Vitro

In vitro activity: Formoterol restored Dex sensitivity by inhibiting phosphorylation of GR-Ser226 and JNK1. Formoterol (FM), but not SM, partially inhibited H(2) O(2) -induced PI3Kδ-dependent (PKB) phosphorylation. H(2) O(2) decreased SM-induced cAMP production in U937 cells, but did not significantly affect the response to FM.

Kinase Assay: Formoterol(Arformoterol) is a novel highly β2-selective adrenergic agonist and holds promise as a β2-agonist that could impart selective beneficial metabolic effects.

Cell Assay:

In Vivo

Mice exposed to formoterol for 24 or 72 h exhibited increases in kidney and heart mtDNA copy number, peroxisome proliferator-activated receptor γ coactivator 1α, and multiple genes involved in the mitochondrial electron transport chain (F0 subunit 6 of transmembrane F-type ATP synthase, NADH dehydrogenase subunit 1, NADH dehydrogenase subunit 6, and NADH dehydrogenase [ubiquinone] 1β subcomplex subunit 8). Formoterol and ritodrine inhibited the amplitude and frequency of rat uterine contraction, with IC50 values of 3.8 x 10(-10) and 4.7 x 10(-7) M, respectively.

Animal model

Mouse

Formulation & Dosage

References

Am J Respir Cell Mol Biol. 2011 Jul; 45(1): 88–94; BMC Pediatr. 2012 Mar 7;12:21.

CAS NO:	183814-30-4
规格:	≥98%

包装	价格(元)
25mg	电议
50mg	电议
100mg	电议
250mg	电议
500mg	电议
1g	电议