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Emicerfont(GW876008)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Emicerfont(GW876008)图片
CAS NO:786701-13-1
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍
Emicerfont (GW876008) 是一种促肾上腺皮质激素释放因子 1 型 (CRF1) 受体拮抗剂,IC50 为 66 nM。
Cas No.786701-13-1
别名GW876008
Canonical SMILESCC1=CC(OC)=CC=C1N(CC2)C3=C2C(N4C=CC(N5CCN([H])C5=O)=N4)=CC(C)=N3
分子式C22H24N6O2
分子量404.46
溶解度Soluble in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Emicerfont is a corticotropin-releasing factor type 1 (CRF1) receptor antagonist with an IC50 of 66 nM.

Emicerfont is a corticotropin-releasing factor type 1 (CRF1) receptor antagonist with an IC50 of 66 nM[1].

At concentration of 10 mg/kg, Emicerfont reduces i.c.v. CRF-induced gerbil forepaw treading and marmoset defensive postures. Emicerfont also reduces rat pup ultrasonic vocalization at concentration of 30 mg/kg[1].

[1]. Zorrilla EP, et al. Behavioral, biological, and chemical perspectives on targeting CRF(1) receptor antagonists to treat alcoholism. Drug Alcohol Depend. 2013 Mar 1;128(3):175-86.