| CAS NO: | 1254575-18-2 |
| 规格: | ≥98% |
| 包装 | 价格(元) |
| 10mg | 电议 |
| 25mg | 电议 |
| 50mg | 电议 |
| 100mg | 电议 |
| 250mg | 电议 |
| 500mg | 电议 |
| Molecular Weight (MW) | 460.48 |
|---|---|
| Formula | C23H28N2O8 |
| CAS No. | 1254575-18-2 (maleate); |
| Storage | -20℃ for 3 years in powder form |
| -80℃ for 2 years in solvent | |
| Solubility (In vitro) | DMSO: ≥ 50 mg/mL |
| Water: < 1 mg/mL | |
| Ethanol: | |
| Chemical Name | N-[2-Hydroxy-5-[(1R)-1-hydroxy-2-[[(2R)-1-(4-methoxyphenyl)propan-2-yl]amino]ethyl]phenyl]formamide Maleate |
| Synonyms | Arformoterol Maleate; (-)-Formoterol; Arformoterol; (R,R)-Formoterol Maleate; Formoterol; arformoterol; (R,R)-Formoterol; BD 40A; eformoterol; Foradil; Trade names: Atock, Atimos/Atimos Modulite, Foradil/Foradile, Oxeze/Oxis, and Perforomist. |
| In Vitro | In vitro activity: Formoterol restored Dex sensitivity by inhibiting phosphorylation of GR-Ser226 and JNK1. Formoterol (FM), but not SM, partially inhibited H(2) O(2) -induced PI3Kδ-dependent (PKB) phosphorylation. H(2) O(2) decreased SM-induced cAMP production in U937 cells, but did not significantly affect the response to FM. Kinase Assay: Formoterol(Arformoterol) is a novel highly β2-selective adrenergic agonist and holds promise as a β2-agonist that could impart selective beneficial metabolic effects. Cell Assay: |
|---|---|
| In Vivo | Mice exposed to formoterol for 24 or 72 h exhibited increases in kidney and heart mtDNA copy number, peroxisome proliferator-activated receptor γ coactivator 1α, and multiple genes involved in the mitochondrial electron transport chain (F0 subunit 6 of transmembrane F-type ATP synthase, NADH dehydrogenase subunit 1, NADH dehydrogenase subunit 6, and NADH dehydrogenase [ubiquinone] 1β subcomplex subunit 8). Formoterol and ritodrine inhibited the amplitude and frequency of rat uterine contraction, with IC50 values of 3.8 x 10(-10) and 4.7 x 10(-7) M, respectively. |
| Animal model | Mouse |
| Formulation & Dosage | |
| References | Am J Respir Cell Mol Biol. 2011 Jul; 45(1): 88–94; BMC Pediatr. 2012 Mar 7;12:21. |
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