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CL 075
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CL 075图片
CAS NO:256922-53-9
包装:5mg
市场价:2070元

产品介绍
CL 075 (3M002) 是一种具有免疫调节特性的选择性 TLR8 激动剂。
Cas No.256922-53-9
别名2-丙基噻唑并[4,5-C]喹啉-4-胺,3M002
Canonical SMILESCCCC1=NC2=C(N=C3C=CC=CC3=C2S1)N
分子式C13H13N3S
分子量243.33
溶解度Soluble in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

TLR8 agonist. Induces production of TNF-α and IL-12 from peripheral blood mononuclear cells (PBMCs). Promotes maturation of monocyte-derived dendritic cells in combination with Poly(I:C) (Cat.No.4287).

Gorden et al (2005) Synthetic TLR agonists reveal functional differences between human TLR7 and TLR8. J.Immunol. 174 1259 PMID:15661881 |Pang et al (2011) Inhibition of TLR8- and TLR4-induced Type I IFN induction by alcohol is different from its effects on inflammatory cytokine production in monocytes. BMC Immunol. 12 55 PMID:21962237 |Spranger et al (2010) Generation of Th1-polarizing dendritic cells using the TLR7/8 agonist CL075. J.Immunol. 185 738 PMID:20511554