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Rosuvastatin
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Rosuvastatin图片
CAS NO:287714-41-4
包装与价格：
包装价格(元)
50mg电议
100mg电议

产品介绍

化学性质

Physical AppearanceA solid
StorageStore at -20°C
M.Wt481.54
Cas No.287714-41-4
FormulaC22H28FN3O6S
Solubility≥48.2 mg/mL in DMSO; ≥10.78 mg/mL in H2O with ultrasonic; ≥12.4 mg/mL in EtOH with ultrasonic
Chemical Name(E,3R,5S)-7-[4-(4-fluorophenyl)-2-[methyl(methylsulfonyl)amino]-6-propan-2-ylpyrimidin-5-yl]-3,5-dihydroxyhept-6-enoic acid
Canonical SMILESCC(C)C1=NC(=NC(=C1C=CC(CC(CC(=O)O)O)O)C2=CC=C(C=C2)F)N(C)S(=O)(=O)C
运输条件蓝冰运输或根据您的需求运输。
一般建议为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。

资料参考

Rosuvastatin is a competitive inhibitor of HMG-CoA reductase with IC50 of 11 nM.

试验操作

Cell experiment:[1]

Cell lines

Rat isolated hepatocytes

Reaction Conditions

1.12 nM (IC50)

Applications

Rosuvastatin inhibited the incorporation of sodium [14C]acetate into cholesterol with an IC50 value of 1.12 nM, and its inhibitory activity on cholesterol biosynthesis was approximately 100 times more potent than pravastatin.

Animal experiment:[1]

Animal models

Normolipemic male beagle dogs

Dosage form

3 mg/kg/day

Administered orally for 14 days

Applications

In male beagle dogs with normal cholesterol levels, rosuvastatin (3 mg/kg/day) administration for 14 days decreased plasma cholesterol levels by 26%, higher than 18% in the pravastatin treatment group.

Note

The technical data provided above is for reference only.

References:

1. Watanabe M, Koike H, Ishiba T, et al. Synthesis and biological activity of methanesulfonamide pyrimidine- and N-methanesulfonyl pyrrole-substituted 3,5-dihydroxy-6-heptenoates, a novel series of HMG-CoA reductase inhibitors. Bioorganic & Medicinal Chemistry, 1997, 5(2): 437-444.