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M62812
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
M62812图片
CAS NO:613263-00-6
包装与价格:
包装价格(元)
10mg电议
50mg电议

产品介绍
TLR-4 inhibitor
Cas No.613263-00-6
Canonical SMILESNC1=CC=CC=C1OC2=CC=C3C(SN=C3N)=C2.Cl.Cl
分子式C13H11N3OS.2HCl
分子量330.23
溶解度Soluble in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

TLR4 inhibitor. Inhibits LPS-induced NF-κB activation in HEK293 cells (IC50 = 2.4 μg/mL). Also inhibits LPS-induced cytokine production and procoagulant effects in PBMCs and HUVECs. Prolongs survival in a mouse septic shock model.

Nakamura et al (2007) Toll-like receptor 4 signal transduction inhibitor, M62812, suppresses endothelial cell and leukocyte activation and prevents lethal septic shock in mice. Eur.J.Pharmacol. 569 237 PMID:17588563