Belapectin

立即咨询

Belapectin

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1980787-47-0

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品名称

GR-MD-02

产品介绍

Belapectin (GR-MD-02) 是一种半乳凝素-3 (Gal-3) 抑制剂。Belapectin 通过诱导 T 细胞凋亡 (Apoptosis) 来驱动肿瘤诱导的免疫抑制。Belapectin 通过 CD8+ T 细胞依赖机制，促进肿瘤消退并提高荷瘤小鼠生存率。Belapectin 结合Gal-3的 K_i为 2.8 μM。

生物活性

Belapectin (GR-MD-02) is aGalectin-3 (Gal-3)inhibitor. Belapectin drives tumor-induced immunosuppression by inducing T cellApoptosis. Belapectin promotes tumor regression and improves survival of tumor-bearing mice through a CD8+ T cell-dependent mechanism. Belapectin binds to Gal-3 with affinity K_iof 2.8 μM^[1]^[2].

IC₅₀& Target

Ki: 2.8 μM (Galectin-3)^[2]

体外研究
(In Vitro)

Belapectin (0.2 mg/mL, 2 mg/mL; 48 h) 抑制 4T1 和 MCA-205 细胞的增殖，诱导凋亡^[1]。

Apoptosis Analysis^[1]

Cell Line:	TRAMP-C1, 4T1 and MCA-205 cells
Concentration:	0.2 mg/mL, 2 mg/mL
Incubation Time:	48 h
Result:	Decreased the proliferation and resulted a minimal increase in apoptosis of 4T1 and MCA-205 cells. But showed no impact on TRAMP-C1 cell.

体内研究
(In Vivo)

Belapectin (2.4 mg/mouse; 腹腔注射; 每周 3 次, 共 3 周) 仅与 anti-OX40 mAb 联合处理后，才导致肿瘤生长显著减少、存活率相应增加。联合处理还产生了持久的长期记忆，100% 无瘤小鼠被保护免于随后的肿瘤再攻击^[1]。

Animal Model:	Wild-type C57BL/6 and BALB/c mice^[1]
Dosage:	2.4 mg/mouse, accompanied with anti-OX40 mAb (250 μg)
Administration:	Intraperitoneal injection; 3 times per week for 3 weeks
Result:	Inhibited tumor growth. Enhanced the efficacy of checkpoint blockade (aPD-L1) immunotherapy.

CAS 号

1980787-47-0

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.