CAS NO: | 297730-17-7 |
包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
2mg | 电议 |
5mg | 电议 |
10mg | 电议 |
50mg | 电议 |
100mg | 电议 |
200mg | 电议 |
生物活性 | AVN-944 (VX-944) is an orally active, potent, selective, noncompetitive and specific inhibitor ofIMPDH(inosine monophosphate dehydrogenase). AVN-944 is an essential rate-limiting enzyme in de novo guanine nucleotide synthesis. AVN-944 is also an inhibitor ofarenavirusRNA synthesis, and blocksarenavirusinfection. AVN-944 has broad anti-cancer activities, and can be used for multiple myeloma (MM) and acute myeloid leukemia (AML) research[1][2][3]. | ||||||||||||||||||||||||||||||||
体外研究 (In Vitro) | AVN-944 (0-1 μM, 48 h) inhibits growth of human multiple myeloma (MM) cell lines in a dose-dependent manner[1]. Cell Proliferation Assay[1]
Apoptosis Analysis[1]
Western Blot Analysis[1]
Cell Cytotoxicity Assay[1]
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体内研究 (In Vivo) | AVN-944 (0-150 mg/kg, Orally, twice daily) significantly increases the median survival time of leukemia model mice[2].
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Clinical Trial | |||||||||||||||||||||||||||||||||
分子量 | 477.51 | ||||||||||||||||||||||||||||||||
性状 | Solid | ||||||||||||||||||||||||||||||||
Formula | C25H27N5O5 | ||||||||||||||||||||||||||||||||
CAS 号 | 297730-17-7 | ||||||||||||||||||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||||||||||||||||||
储存方式 |
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溶解性数据 | In Vitro: DMSO : 100 mg/mL(209.42 mM;Need ultrasonic) 配制储备液
* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo: 请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照In Vitro方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用;
以下溶剂前显示的百
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