CAS NO: | 69304-47-8 |
包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
25mg | 电议 |
50mg | 电议 |
100mg | 电议 |
200mg | 电议 |
500mg | 电议 |
1 g | 电议 |
生物活性 | Brivudine is a thymidine analogue with antiviral activity, indicated for the early treatment of acute herpes zoster. | ||||||||||||||||
体外研究 (In Vitro) | Brivudine is an analog of thymidine, and is incorporated into the viral DNA. It blocks the action of DNA polymerases, thus inhibiting viral replication. It has a stronger antiviral effect against the varicella-zoster virus compared with reference compounds such as aciclovir or penciclovir[1]. It has high, selective activity against varicella zoster virus (VZV), inhibiting VZV replication, possibly through competitive inhibition of viral DNA polymerase, or by acting as an alternative substrate to deoxythymidine triphosphate, causing viral DNA strand breakage[2]. | ||||||||||||||||
体内研究 (In Vivo) | At a dose of 125 mg once daily, brivudine has proved to be superior to aciclovir with respect to reducing the period of new blister production, and has shortened the duration of post-herpetic neuralgia[1]. | ||||||||||||||||
Clinical Trial | |||||||||||||||||
分子量 | 333.14 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C11H13BrN2O5 | ||||||||||||||||
CAS 号 | 69304-47-8 | ||||||||||||||||
中文名称 | 溴比夫定;溴夫定 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 |
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溶解性数据 | In Vitro: DMSO : 200 mg/mL(600.35 mM;Need ultrasonic) 配制储备液
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以下溶剂前显示的百
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