Sevirumab (MSL-109) 是一种人抗巨细胞病毒 (CMV) IgG1 中和单克隆抗体。Sevirumab 识别 CMV gH 复合物，抑制 CMV 复制，EC50为 0.3 μg/mL。
| 生物活性 | Sevirumab (MSL-109) is a humanIgG1neutralizing monoclonal antibody against cytomegalovirus (CMV). Sevirumab recognizesCMVgH complexes and inhibitsCMVreplication with anEC50of 0.3 μg/mL[1][2]. |
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体外研究
(In Vitro) | Sevirumab (MSL-109) 扰乱 gH/gL 同型二聚体，而不是取消二聚。Sevirumab 可以将二聚体在足够的距离上分开，以减少荧光共振能量转移 (FRET)，并最终阻止正常的 gH/gL 功能[2]。
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| 储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |
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