CAS NO: | 176161-24-3 |
包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
5mg | 电议 |
10mg | 电议 |
50mg | 电议 |
100mg | 电议 |
200mg | 电议 |
500mg | 电议 |
生物活性 | Maribavir is a potent inhibitor of histone phosphorylation catalyzed by wild-type pUL97 in vitro, with anIC50of 3 nM. Maribavir has potent antiviral activity againstHCMVand Epstein-Barr virus (EBV). | ||||||||||||||||
IC50& Target | HCMV[1] | ||||||||||||||||
体外研究 (In Vitro) | Maribavir is a potent inhibitor of the autophosporylation of the wild type and all the major Ganciclovir (GCV) resistant UL97 mutants analysed with a mean IC50of 35 nM. The M460I mutation results in hypersensitivity to Maribavir with an IC50of 4.8 nM. A Maribavir resistant mutant of UL97 (L397R) is functionally compromised as both a Ganciclovir kinase and a protein kinase (~ 10% of wild type levels). Enzyme kinetic experiments demonstrate that Maribavir is a competitive inhibitor of ATP with a Kiof 10 nM[1]. Maribavir (1263W94) inhibits viral replication in a dose-dependent manner, with IC50of 0.12±0.01 μM as measured by a multicycle DNA hybridization assay. The pUL97 protein kinase is strongly inhibited by Maribavir, with 50% inhibition occurring at 3 nM[2]. | ||||||||||||||||
Clinical Trial | |||||||||||||||||
分子量 | 376.24 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C15H19Cl2N3O4 | ||||||||||||||||
CAS 号 | 176161-24-3 | ||||||||||||||||
中文名称 | 马立巴韦 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 |
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溶解性数据 | In Vitro: DMSO : 200 mg/mL(531.58 mM;Need ultrasonic) 配制储备液
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以下溶剂前显示的百
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