CAS NO: | 233254-24-5 |
包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
5mg | 电议 |
10mg | 电议 |
25mg | 电议 |
50mg | 电议 |
100mg | 电议 |
200mg | 电议 |
500mg | 电议 |
生物活性 | Tomeglovir is a potent anti-CMVagent, inhibiting processing of viral DNA-concatemers, withIC50s of 0.34 μM and 0.039 μM for HCMV and MCMV. | ||||||||||||||||
IC50& Target | IC50: 0.34 μM (HCMV), 0.039 μM (MCMV)[1] | ||||||||||||||||
体外研究 (In Vitro) | Tomeglovir (BAY 38-4766) is a potent anti-CMV agent, with IC50s of 0.34 μM and 0.039 μM for HCMV and MCMV. Tomeglovir also suppresses HELF and NIH 3T3 cells, with CC50s of 85 μM and 62.5 μM, respectively[1]. Tomeglovir (BAY 38-4766) inhibits HCMV Davis and various monkey CMV strains with EC50s of 1.03 ± 0.57 μM and< 1 μM[2]. | ||||||||||||||||
体内研究 (In Vivo) | Tomeglovir (BAY 38-4766; 3, 10, 30, 100 mg/kg, p.o.) dose-dependently reduces MCMV-DNA in salivary glands, livers and kidneys of MCMV-infected NOD-SCID mice, and prolongs the survival of the mice. Tomeglovir (10, 25 and 50 mg/kg) shows antiviral activity in the hollow fiber mouse model[1]. Tomeglovir (BAY 38-4766) shows antiviral activity in SCID mice with MCMV, and the LD50is >2000 mg/kg in mice and rats[2]. | ||||||||||||||||
分子量 | 441.54 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C23H27N3O4S | ||||||||||||||||
CAS 号 | 233254-24-5 | ||||||||||||||||
中文名称 | 托美洛韦 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 |
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溶解性数据 | In Vitro: DMSO : ≥ 108 mg/mL(244.60 mM) *"≥" means soluble, but saturation unknown. 配制储备液
* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 |