CAS NO: | 950225-08-8 |
包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
5mg | 电议 |
10mg | 电议 |
50mg | 电议 |
100mg | 电议 |
生物活性 | TTP-8307 is a potent inhibitor of the replication of severalrhino- and enteroviruses. TTP-8307 inhibits coxsackievirus B3 (CVB3; EC50=1.2 μM) and poliovirus by interfering with the synthesis ofviral RNA. TTP-8307 exerts antiviral activity through oxysterol-binding protein(OSBP)[1][2]. | ||||||||||||||||
体外研究 (In Vitro) | TTP-8307 targets the nonstructural protein 3A, inhibits the replication of coxsackievirus B3 (CVB3 Nancy) with EC50of 1.2 μM. TTP-8307 inhibits the replication of coxsackievirus B3 and the three poliovirus Sabin strains, as well as coxsackieviruses A16 and A21 (EC50of 0.85 and 5.34 μM). TTP-8307 inhibits human rhinoviruses (HRVs) 2, 29, 39, 45, 63, and 85. Mutations in the nonstructural protein 3A confer resistance to the novel enterovirus replication inhibitor TTP-8307[1]. | ||||||||||||||||
分子量 | 436.48 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C27H21FN4O | ||||||||||||||||
CAS 号 | 950225-08-8 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 |
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溶解性数据 | In Vitro: DMSO : 100 mg/mL(229.11 mM;Need ultrasonic) 配制储备液
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以下溶剂前显示的百
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