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NHC-diphosphate
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
NHC-diphosphate图片
CAS NO:39023-73-9
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议
50mg电议
100mg电议

产品介绍
NHC-diphosphate 是 NHC (HY-125033) 的活性胞内磷酸化代谢物 (intracellular metabolite),以二磷酸盐的形式存在。NHC 是一种嘧啶核糖核苷,是一种有效的抗病毒剂 (anti-virus agent)。NHC 有效抑制委内瑞拉马脑炎病毒 (VEEV)、基孔肯亚病毒 (CHIKV) 和丙型肝炎病毒 (HCV) 的复制。
生物活性

NHC-diphosphate is an active phosphorylated intracellularmetabolite of β-d-N4-Hydroxycytidine (NHC) (HY-125033) as a diphosphate form[1]. NHC is a pyrimidine ribonucleoside and behaves as a potentanti-virus agent. NHC effectively inhibits the replication ofvenezuelan equine encephalitisvirus (VEEV),Chikungunyavirus (CHIKV) andhepatitisC virus (HCV)[1].

体外研究
(In Vitro)

Huh-7 cells are incubated with (10-50 μM; 4 h) NHC or a McGuigan phosphoramidate prodrug of NHC.
Intracellular levels of the parental compounds and phosphorylated metabolites are measured using LC-MS/MS. Small amounts of NHC-monophosphate (MP) and NHC-diphosphate (DP; HY-135867D) can be observed, while NHC-triphosphate remains the most abundant metabolite.[1].

分子量

419.18

性状

Solid

Formula

C9H15N3O12P2

CAS 号

39023-73-9

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

溶解性数据
In Vitro: 

H2O : 160 mg/mL(381.70 mM;Need ultrasonic)

配制储备液
浓度溶剂体积质量1 mg5 mg10 mg
1 mM2.3856 mL11.9281 mL23.8561 mL
5 mM0.4771 mL2.3856 mL4.7712 mL
10 mM0.2386 mL1.1928 mL2.3856 mL
*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80℃, 6 months; -20℃, 1 month (protect from light, stored under nitrogen)。-80℃ 储存时,请在 6 个月内使用,-20℃ 储存时,请在 1 个月内使用。