CAS NO: | 39023-73-9 |
包装 | 价格(元) |
1mg | 电议 |
5mg | 电议 |
10mg | 电议 |
50mg | 电议 |
100mg | 电议 |
生物活性 | NHC-diphosphate is an active phosphorylated intracellularmetabolite of β-d-N4-Hydroxycytidine (NHC) (HY-125033) as a diphosphate form[1]. NHC is a pyrimidine ribonucleoside and behaves as a potentanti-virus agent. NHC effectively inhibits the replication ofvenezuelan equine encephalitisvirus (VEEV),Chikungunyavirus (CHIKV) andhepatitisC virus (HCV)[1]. | ||||||||||||||||
体外研究 (In Vitro) | Huh-7 cells are incubated with (10-50 μM; 4 h) NHC or a McGuigan phosphoramidate prodrug of NHC.Intracellular levels of the parental compounds and phosphorylated metabolites are measured using LC-MS/MS. Small amounts of NHC-monophosphate (MP) and NHC-diphosphate (DP; HY-135867D) can be observed, while NHC-triphosphate remains the most abundant metabolite.[1]. | ||||||||||||||||
分子量 | 419.18 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C9H15N3O12P2 | ||||||||||||||||
CAS 号 | 39023-73-9 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 | -20°C, protect from light, stored under nitrogen *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen) | ||||||||||||||||
溶解性数据 | In Vitro: H2O : 160 mg/mL(381.70 mM;Need ultrasonic) 配制储备液
* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 |