o-Vanillin (2-Vanillin) 是一种天然产物，可从Vanilla planifolia， Pinus koraiensis的果实中提取。o-Vanillin 是一种有效的抗真菌剂。o-Vanillin 通过破坏细胞壁和细胞膜的完整性来抑制菌丝的生长。o-Vanillin 抑制 Doxorubicin (HY-15142A) 和 4-氢过氧环磷酰胺诱导的 NF-κB 激活。
| 生物活性 | o-Vanillin (2-Vanillin) is a nature product, could be extracted fromVanilla planifolia, Pinus koraiensisfruit. o-Vanillin is a potent antifungal agent. o-Vanillin inhibits the growth of mycelia by disrupting the integrity of cell walls and cell membranes. o-Vanillin inhibitsDoxorubicin(HY-15142A)- and 4-hydroperoxycyclophosphamide-inducedNF-κBactivation[1][2]. |
体外研究
(In Vitro) | o-Vanillin (2-Vanillin; 0-125 μg/mL; 24-72 h) inhibits the mycelial growth ofA. flavusin a dose-dependent manner[1].
o-Vanillin (0-100 μg/mL; 48 h;A. flavus) changes the morphology of mycelia and induces irregular shrinkage of the mycelia[1].
o-Vanillin (0-100 μg/mL;A. flavus) decreases the protein content of the cell wall surface and the content of β-1,3-glucan[1].
o-Vanillin (0-100 μg/mL;A. flavus) destroys cell membrane integrity. o-Vanillin releases cell constituents and decreases extracellular pH value[1].
o-Vanillin (0-100 μg/mL) could effectively inhibit the growth ofA. flavuson corn kernels[1].
o-Vanillin (0-250 μM) inhibits doxorubicin-mediated induction of NFqB activity by 65% in A375/NFqB-Luc cells. o-Vanillin suppresses 4-HC-induced activity by 43%[2].
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体内研究
(In Vivo) | o-Vanillin (2-Vanillin; 60 mg/kg; p.o.; daily, for 5 d) inhibits tumor growth in mice bearing A375 human melanoma xenografts[2].
| Animal Model: | Male NSG mice with A375 human melanoma xenografts (12-16 weeks of age)[2] | | Dosage: | 60 mg/kg | | Administration: | Oral administration; daily, for 5 days | | Result: | Delayed the growth of A375 human melanoma xenografts in immunodeficient NSG mice. |
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| 运输条件 | Room temperature in continental US; may vary elsewhere. |
| 储存方式 | 4°C, stored under nitrogen *In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen) |
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