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Doxorubicin
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Doxorubicin图片
CAS NO:23214-92-8
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品名称
阿霉素
Hydroxydaunorubicin
产品介绍
Doxorubicin (Hydroxydaunorubicin) 是一种有细胞毒性的蒽环类抗生素,常用作肿瘤化疗剂。Doxorubicin 抑制拓扑异构酶 II (topoisomerase-II),IC50为 2.67 μM,从而抑制 DNA 复制。Doxorubicin 下调AMPK的基础磷酸化以及下游 acetyl-CoA 羧化酶。Doxorubicin 诱导凋亡 (apoptosis) 和自噬 (autophagy)。Doxorubicin 抑制人 DNA 拓扑异构酶 I (topoisomerase I),IC50为 0.8 μM。
生物活性

Doxorubicin (Hydroxydaunorubicin), a cytotoxic anthracyclineantibiotic, is an anti-cancer chemotherapy agent. Doxorubicin inhibitstopoisomeraseIIwith anIC50of 2.67 μM, thus stopping DNA replication. Doxorubicin reduces basal phosphorylation ofAMPKand its downstream targetacetyl-CoA carboxylase. Doxorubicin inducesapoptosisandautophagy[1][2]. Doxorubicin inhibits humanDNAtopoisomeraseIwith anIC50of 0.8 μM[3].

IC50& Target[1][2][3][7]

Topoisomerase I

0.8 μM (IC50)

Topoisomerase II

2.67 μM (IC50)

Daunorubicins/Doxorubicins

 

HIV-1

 

体外研究
(In Vitro)

Combination of Doxorubicin (Hydroxydaunorubicin) and Simvastatin in the highest tested concentrations (2 μM and 10 μM, respec-tively) kills 97% of the Hela cells[4].

体内研究
(In Vivo)

Mice bearing PC3 xenografts are injected with 2, 4 or 8 mg/kg Doxorubicin (Hydroxydaunorubicin) and tumor volume is measured over time. A dose of 2 mg/kg does not affect tumor growth while higher dosages delay tumor growth initially (p<0.05 at days 18 and 22), 4 mg/kg or 8 mg/kg Doxorubicin significantly reduces levels of c-FLIP in PC3 xenografts[5]. A single intraperitoneal injection 10 mg/kg (Doxorubicin 1) is administered in rats, 10 daily intraperitoneal injections of 1 mg/kg (Doxorubicin 2), or in 5 weekly intraperitoneal injections of 2 mg/kg (Doxorubicin 3). An 80% mortality rate is observed at day 28 in Doxorubicin 1, whereas Doxorubicin 2 and Doxorubicin 3 reached 80% mortality at days 107 and 98, respectively. Fractional shortening decreased by 30% at week 2 in Doxorubicin DOX1, 55% at week 13 in Doxorubicin 2, and 42% at week 13 in Doxorubicin 3[6].

Clinical Trial
分子量

543.52

Formula

C27H29NO11

CAS 号

23214-92-8

中文名称

阿霉素;多柔比星

结构分类
  • Quinones
  • Anthraquinones
  • Phenols
  • Polyphenols
来源

Streptomyces peucetius.

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

溶解性数据
In Vivo:
  • 1.

    Doxorubicin (dissolved with distilled water) is incorporated into 0.035% CaCl2solution[5].

  • 2.

    Doxorubicin (Adriamycin) is prepared in vehicle (PBS)[6].