CAS NO: | 2319747-14-1 |
包装 | 价格(元) |
5mg | 电议 |
10mg | 电议 |
25mg | 电议 |
50mg | 电议 |
100mg | 电议 |
200mg | 电议 |
500mg | 电议 |
生物活性 | LDC4297 hydrochloride is a selective inhibitor ofCDK7with anIC50value of 0.13 nM. LDC4297 hydrochloride inhibits human cytomegalovirus (HCMV) replication with anEC50value of 24.5 nM. LDC4297 hydrochloride shows broad antiviral activities toHerpesviridae,Adenoviridae,Poxviridae,RetroviridaeandOrthomyxoviridaewithEC50values of 0.02-1.21 μM. LDC4297 hydrochloride can be used for the research ofinfection[1]. | ||||||||
IC50& Target |
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体外研究 (In Vitro) | LDC4297 hydrochloride (0-10 μM; 6 d) dose-dependently inhibits HCMV replication with an EC50value of 24.5 nM[1].LDC4297 hydrochloride (0-10 μM; 4 d) shows anti-proliferative activity to primary cultures of fibroblasts derived from human (HFF) with a GI50value of 4.5 μM[1].LDC4297 hydrochloride (20 μM; 12-96 h) shows anti-HCMV activity through a multifaceted mode of action that involves an interference with virus-induced Rb phosphorylation[1].LDC4297 hydrochloride (0-10 μM; 7 d) shows broad antiviral activities to HCMV, GPCMV, MCMV, HVV-6A, HSV-1, HSV-2, VZV, EBV, HAdV-2, Vaccinia virus, HIV-1 (nl4-3), HIV-1 (4LIG7) and Influenza A virus with EC50values of 0.02, 0.05, 0.07, 0.04, 0.02, 0.27, 0.06, 1.21, 0.25, 0.77, 1.04, 1.13 and 0.99 μM, respectively[1]. Western Blot Analysis[1]
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体内研究 (In Vivo) | LDC4297 hydrochloride (100 mg/kg; p.o. once) shows promising pharmacokinetic analyses[1].
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分子量 | 468.98 | ||||||||
性状 | Solid | ||||||||
Formula | C23H29ClN8O | ||||||||
CAS 号 | 2319747-14-1 | ||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||
储存方式 | 4°C, sealed storage, away from moisture and light *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light) |