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Abacavir hydrochloride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Abacavir hydrochloride图片
CAS NO:136777-48-5
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
Abacavir hydrochloride 是一种具有口服活性、竞争性核苷酸逆转录酶 (nucleoside reverse transcriptase) 抑制剂。 Abacavir hydrochloride 可抑制HIV的复制。Abacavir hydrochloride 在前列腺癌细胞系中显示出抗癌活性。Abacavir hydrochloride 可透过血脑屏障,抑制端粒酶 (telomerase) 活性。
生物活性

Abacavir hydrochloride is a competitive, orally activenucleosidereverse transcriptaseinhibitor. Abacavir hydrochloride can inhibits the replication ofHIV. Abacavir hydrochloride shows anticancer activity in prostatecancercell lines. Abacavir hydrochloride can trespass the blood-brain-barrier and suppressestelomeraseactivity[1][2][3].

体外研究
(In Vitro)

Abacavir hydrochloride (15 and 150 μM, 0-120 h) inhibits cell growth, affects cell cycle progression, induces senescence and modulates LINE-1 mRNA expression in prostate cancer cell lines[1].
Abacavir hydrochloride (15 and 150 μM, 18 h) significantly reduces cell migration and inhibits cell invasion[1].
Abacavir hydrochloride induces fat apoptosis[4].

Cell Proliferation Assay[1]

Cell Line:PC3, LNCaP and WI-38
Concentration:15 μM and 150 μM
Incubation Time:0, 24, 48, 72 and 96 hours
Result:Showed a dose-dependent growth inhibition on PC3 and LNCaP.

Cell Cycle Analysis[1]

Cell Line:PC3, LNCaP and WI-38
Concentration:150 μM
Incubation Time:0, 18, 24, 48, 72, 96 and 120 hours
Result:Caused a very high accumulation of cells in S phase in PC3 and LNCaP cells, and G2/M phase increment was observed in PC3 cells.

Cell Migration Assay[1]

Cell Line:PC3, LNCaP and WI-38
Concentration:15 and 150 μM
Incubation Time:18 hours
Result:Significantly reduced cell migration.

Cell Invasion Assay[1]

Cell Line:PC3, LNCaP and WI-38
Concentration:15 and 150 μM
Incubation Time:18 hours
Result:Significantly inhibited cell invision.
体内研究
(In Vivo)

Abacavir hydrochloride (100 and 200 mg/kg, p.o.; 4 h) dose-dependently promotes thrombus formation[2].
Abacavir hydrochloride (50 mg/kg/d; i.p.; 14 d) with 0.1 mg/kg/dDecitabine(HY-A0004) enhances survival of high-risk medulloblastoma-bearing mice[3].

Animal Model:Male mice (9-weeks old, 22-30 g) - wild-type (WT) C57BL/6 or homozygous knockout (P2rx7 KO, B6.129P2-P2rx7tm1Gab/J)[2]
Dosage:Route 1: 2.5, 5, and 7.5 μg/mL, 100 μL
Route 2: 100 and 200 mg/kg
Administration:Intrascrotal or oral administration for 4 h
Result:Dose-dependently promoted thrombus formation.
Animal Model:NSGTMmice, patient-derived xenograft (PDX) cells of non-WNT/non-SHH, Group 3 and of SHH/ TP53-mutated medulloblastoma[3]
Dosage:50 mg/kg/d with 0.1 mg/kg/d Decitabine
Administration:Intraperitoneal injection, daily for 14 days
Result:Inhibited tumor growth and enhanced mouse survival.
Clinical Trial
分子量

322.79

Formula

C14H19ClN6O

CAS 号

136777-48-5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.