CAS NO: | 50-63-5 |
包装 | 价格(元) |
100mg | 电议 |
200mg | 电议 |
500mg | 电议 |
1 g | 电议 |
5 g | 电议 |
生物活性 | Chloroquine phosphate is anantimalarialand anti-inflammatory agent widely used to treat malaria and rheumatoid arthritis. Chloroquine phosphate is anautophagyandtoll-like receptors (TLRs)inhibitor. Chloroquine phosphate is highly effective in the control ofSARS-CoV-2 (COVID-19)infectionin vitro (EC50=1.13 μM)[1][2][3][4]. | ||||||||||||||||
IC50& Target[1][2][3][5] |
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体外研究 (In Vitro) | Chloroquine (CHQ, 20 μM) inhibits IL-12p70 release and reduces Th1-priming capacity of activated human monocyte-derived Langerhans-like cells (MoLC). Chloroquine (CHQ, 20 μM) enhances IL-1–induced IL-23 secretion in MoLC and subsequently increases IL-17A release by primed CD4+T cells[1]. Chloroquine (25 μM) suppresses MMP-9 mRNA expression in normoxia and hypoxia in parental MDA-MB-231 cells. Chloroquine has cell-, dose- and hypoxia-dependent effects on MMP-2, MMP-9 and MMP-13 mRNA expression[2]. TLR7 and TLR9 inhibition using IRS-954 or chloroquine significantly reduces HuH7 cell proliferation in vitro[3]. | ||||||||||||||||
体内研究 (In Vivo) | Chloroquine (80 mg/kg, i.p.) does not prevent the growth of the triple-negative MDA-MB-231 cells with high or low TLR9 expression levels in the orthotopic mouse model[2]. TLR7 and TLR9 inhibition using IRS-954 or chloroquine significantly inhibits tumour growth in the mouse xenograft model. HCC development in the DEN/NMOR rat model is also significantly inhibited by chloroquine[3]. | ||||||||||||||||
Clinical Trial | |||||||||||||||||
分子量 | 515.86 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C18H32ClN3O8P2 | ||||||||||||||||
CAS 号 | 50-63-5 | ||||||||||||||||
中文名称 | 磷酸氯喹;氯喹宁二磷酸盐;氯化喹啉磷酸盐;氯喹磷酸盐;磷酸氯化喹啉;磷酸氯喹啉;二磷酸氯喹;氯喹二磷酸盐 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 | 4°C, sealed storage, away from moisture and light *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light) | ||||||||||||||||
溶解性数据 | In Vitro: H2O : ≥ 33 mg/mL(63.97 mM) DMSO :< 1 mg/mL (ultrasonic)(insoluble or slightly soluble) *"≥" means soluble, but saturation unknown. 配制储备液
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