CAS NO: | 26305-03-3 |
包装 | 价格(元) |
10mg | 电议 |
50mg | 电议 |
100mg | 电议 |
200mg | 电议 |
生物活性 | Pepstatin (Pepstatin A) is a specific, orally activeaspartic proteaseinhibitor produced by actinomycetes, withIC50s of 4.5 nM, 6.2 nM, 150 nM, 290 nM, 520 nM and 260 nM for hemoglobin-pepsin, hemoglobin-proctase, casein-pepsin, casein-proctase, casein-acid protease and hemoglobin-acid protease, respectively. Pepstatin also inhibitsHIV protease[1][2]. | ||||||||||||||||
IC50& Target | IC50: 4.5 nM (Hemoglobin-pepsin), 6.2 nM (Hemoglobin-proctase), 150 nM (Casein-pepsin), 260 nM (Hemoglobin-acid protease), 290 nM (Casein-proctase), 520 nM (Casein-acid protease)[1] | ||||||||||||||||
体外研究 (In Vitro) | Pepstatin (Pepstatin A) (7 μM; 48 h) affects the intracellular processing of HIV-specific gag protein[2]. | ||||||||||||||||
体内研究 (In Vivo) | Pepstatin (Pepstatin A) has a very low toxicity, with LD50s of 1090 mg/kg, 875 mg/kg, 820 mg/kg and 450 mg/kg for mice, rats, rabbits, and dogs by i.p. route, and >2000 mg/kg for all species by oral route[1].
| ||||||||||||||||
分子量 | 685.89 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C34H63N5O9 | ||||||||||||||||
CAS 号 | 26305-03-3 | ||||||||||||||||
Sequence | IsoValeryl-Val-Val-Sta-Ala-Sta-OH | ||||||||||||||||
Sequence Shortening | IsoVeryl-VV-Sta-A-Sta-OH | ||||||||||||||||
中文名称 | 胃酶抑素;抑肽素;胃蛋白酶抑制剂;胃酶抑素A | ||||||||||||||||
结构分类 |
| ||||||||||||||||
来源 | actinomycetes | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 | Sealed storage, away from moisture
*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) | ||||||||||||||||
溶解性数据 | In Vitro: DMSO : ≥ 33.33 mg/mL(48.59 mM) *"≥" means soluble, but saturation unknown. 配制储备液
* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo: 请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照In Vitro方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用;
以下溶剂前显示的百
|