YL-939 是一种有效的铁死亡 (ferroptosis) 抑制剂。 YL-939 通过靶向 PHB2/铁蛋白/铁轴来抑制铁死亡。
| 生物活性 | YL-939 is a potentferroptosisinhibitor. YL-939 inhibitsferroptosisby targeting the PHB2/ferritin/iron axis[1]. |
体外研究
(In Vitro) | YL-939 (0.01-10 μM) 有效保护细胞免于铁死亡，对 HT-1080, Miapaca-2, Calu-1, HCT116 和 SHSY5Y 细胞的 IC50值为 0.14 μM、0.25 μM、0.16 μM、0.16 μM 和 0.24 μM[1].
YL-939 (5 μM；10 小时；ES-2 细胞) 降低细胞溶质、膜脂中的 ROS 水平[1]。
YL-939 (5 μM；1-10 h；ES-2 细胞) 具有 PHB2 生物学靶标[1]。
YL-939 (3 μM；10 h；ES-2 细胞) 以浓度依赖性方式改善铁蛋白表达并阻断自噬体/溶酶体，从而抑制铁蛋白自噬[1]。
Western Blot Analysis[1] | Cell Line: | ES-2 cells | | Concentration: | 5 μM | | Incubation Time: | 1, 5, 7.5, and 10 hours | | Result: | Pulled down PHB2 protein by the probe. |
Western Blot Analysis[1] | Cell Line: | ES-2 cells | | Concentration: | 3 μM | | Incubation Time: | 10 hours | | Result: | Increased the expression of nuclear receptor coactivator 4 (NCOA4) in a dose-dependent manner. |
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体内研究
(In Vivo) | YL-939 (3 mg/kg；腹腔注射；单次注射) 改善对乙酰氨基酚(APAP) 中的肝损伤-诱导的急性肝损伤模型[1].
| Animal Model: | Acetaminophen(APAP)-induced male C57BL/6J mouse[1] | | Dosage: | 3 mg/kg | | Administration: | Intraperitoneal injection; single injection | | Result: | Inhibited the cell death and inflammatory infiltration in the liver tissues of male C57BL/J6 mice that received APAP. |
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| 运输条件 | Room temperature in continental US; may vary elsewhere. |
| 储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |
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