dTAGV-1-NEG TFA

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dTAGV-1-NEG TFA

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品介绍

dTAGV-1-NEG TFA 是一种非对映异构体，是 dTAGV-1 的异双功能阴性对照。dTAGV-1-NEG TFA 是一种 FKBP12^F36V选择性降解剂。

生物活性

dTAGV-1-NEG TFA is a diastereomer and as a heterobifunctional negative control of dTAGV-1. dTAGV-1-NEG TFA is an FKBP12^F36V-selective degrader^[1].

体外研究
(In Vitro)

dTAGV-1-NEG TFA (1-10 μM; 24 h) not induces the degradation of FKBP12^F36V-Nluc on 293FT FKBP12^F36V-Nluc or FKBP12^WT-Nluc cells^[1].
dTAGV-1-NEG TFA (500 nM; 24 h) dose not induce the degradation of KRAS^G12Vprotein in PATU-8902 FKBP12^F36V-KRASG12V and KRAS^–/–cells^[1].

Western Blot Analysis^[1]

Cell Line:	PATU-8902 FKBP12^F36V-KRASG12V, KRAS^–/–cells
Concentration:	50, 500 nM
Incubation Time:	24 hours
Result:	Not induced the degradation of KRAS^G12Vprotein.

Cell Viability Assay^[1]

Cell Line:	EWS502 FKBP12F36V-GFP cells
Concentration:	1 μM
Incubation Time:	0, 2, 4, 6, 8 days
Result:	Showed relative growth of cells same as the control group, higher than dTAGV-1 treated group.

分子量

1361.56

Formula

C₇₀H₉₁F₃N₆O₁₆S

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.