MLKL-IN-3 (compound 66) is a potentMLKL(Mixed lineage kinase domain-like protein) inhibitor. MLKL-IN-3 inhibitsnecroptosisin HT-29 cells and acts downstream of MLKL phosphorylation, withEC₅₀of 31 nM^[1].

MLKL-IN-3 (compound 66) (1 μM, 24 h) inhibits the translocation of MLKL to cell membranes in HT-29 cells^[1].
MLKL-IN-3 does not affect the phosphorylation status of RIPK1 and MLKL^[1].

MLKL-IN-3 (compound 66) shows T1/2 over 48 h and more than 150-fold lower reaction rates with glutathione (GSH), which potentially decreased their off-target effects and cell toxicity^[1].

589.04

C₃₁H₂₉ClN₄O₆

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