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MLKL-IN-3
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
MLKL-IN-3图片
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
MLKL-IN-3 (compound 66) 是一种有效的MLKL(混合谱系激酶结构域样蛋白)抑制剂。MLKL-IN-3 可抑制 HT-29 细胞的坏死 (necroptosis),作用于 MLKL 磷酸化的下游,其EC50为 31 nM。
生物活性

MLKL-IN-3 (compound 66) is a potentMLKL(Mixed lineage kinase domain-like protein) inhibitor. MLKL-IN-3 inhibitsnecroptosisin HT-29 cells and acts downstream of MLKL phosphorylation, withEC50of 31 nM[1].

体外研究
(In Vitro)

MLKL-IN-3 (compound 66) (1 μM, 24 h) inhibits the translocation of MLKL to cell membranes in HT-29 cells[1].
MLKL-IN-3 does not affect the phosphorylation status of RIPK1 and MLKL[1].

体内研究
(In Vivo)

MLKL-IN-3 (compound 66) shows T1/2 over 48 h and more than 150-fold lower reaction rates with glutathione (GSH), which potentially decreased their off-target effects and cell toxicity[1].

分子量

589.04

Formula

C31H29ClN4O6

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.