Protein kinase D inhibitor 1

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CAS NO:

2489320-03-6

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品介绍

Protein kinase D inhibitor 1 (compound 17m) 是一种有效的泛PKD抑制剂，IC₅₀为 17~35 nM。Protein kinase D inhibitor 1 可抑制 PKD 依赖性的皮质激素磷酸化。

生物活性

Protein kinase D inhibitor 1 (compound 17m) is a pan-PKDinhibitor, withIC₅₀values ranging from 17 to 35 nM. Protein kinase D inhibitor 1 inhibits PKD-dependent cortactin phosphorylation^[1].

IC₅₀& Target

PKD3

17 ± 8 nM (IC₅₀)

PKD2

35 ± 5 nM (IC₅₀)

PKD1

35 ± 10 nM (IC₅₀)

体外研究
(In Vitro)

Protein kinase D inhibitor 1 (compound 17m) displays excellent PKD2 inhibition with almost no remaining kinase activity at 1 μM^[1].
Protein kinase D inhibitor 1 displays only weak antiproliferative activity, and does not significantly affect PANC-1 cell proliferation at a concentration of 5 μM^[1].
Protein kinase D inhibitor 1 (0-100 μM, 72 h) shows antitumor activity^[1].

Cell Viability Assay^[1]

Cell Line:	LN-229, Capan-1, DND-41, HL-60, Z-138, NCI-H460, HCT-116, K-562
Concentration:	0-100 μM
Incubation Time:	72 h
Result:	Inhibited of tumor cell growth of LN-229, Capan-1, DND-41, HL-60, Z-138, NCI-H460, HCT-116, and K-562, with IC₅₀values of 80.6 ± 7, 40.7 ± 14.5, 42.7 ± 4.9, 17.9 ± 4.1, 35.3 ± 10.4, >95.8, >100, and >100, respectively.

分子量

347.42

Formula

C₁₉H₂₁N₇

CAS 号

2489320-03-6

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.