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LLP-3
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
LLP-3图片
CAS NO:1453835-43-2
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
LLP-3 是一种有效的Survivin抑制剂,可扰乱癌细胞中的 Survivin-Ran 蛋白复合物作用。LLP-3 可用于多形性胶质母细胞瘤(GBM) 的研究。
生物活性

LLP-3 is a potentSurvivininhibitor that disrupts the Survivin-Ran interaction incancercells. LLP-3 can be used in the research of Glioblastoma multiforme (GBM)[1].

IC50& Target

Survivin[1]

体外研究
(In Vitro)

LLP-3 (20 μM, 24 h) impaires the binding of Survivin to Smac/DIABLO (proapoptotic protein), without affecting the interaction of Survivin with other chromosomal passenger complex (CPC) proteins[1].
LLP-3 (20 μM, 24 h) decreases the Survivin-Ran interaction in U87 cells[1].
LLP-3 (20 μM, 24 h) arrests cell in G0-G1 phase and subsequent tumor cell death[1].
LLP-3 (20 μM, 24 h) triggers caspase-dependent apoptosis in HT1080 cells[1].
LLP-3 (0-100 μM, 72 h) inhibits tumor cells survival by p53-mediated inhibition[1].

Cell Viability Assay[1]

Cell Line:U87E6, U87MG cell
Concentration:0-100 μM
Incubation Time:72 h
Result:Inhibited tumor cells survival with IC50values of 13.6 μM (U87E6) and 38.1 μM (U87MG).

Cell Cycle Analysis[1]

Cell Line:U87 cells
Concentration:20 μM
Incubation Time:24 h
Result:Reduced the proportions of cells in the S and G2-M phases (from 9% to 5%, and from 25% to 17%, respectively).
Increased G0-G1 cell population (from 60% to 74%).

Immunofluorescence[1]

Cell Line:U87, HT1080 cells
Concentration:40 μM
Incubation Time:24 h
Result:Weakened the colocalization of TPX2 with the acetylated α-tubulin.
体内研究
(In Vivo)

LLP-3 (intraperitoneal injection, 25 mg/kg, for 10 days) prolongs survival of GBM sphere-derived tumor mice[1].

Animal Model:GBM sphere-derived tumor models (GBM83 and 1600)[1]
Dosage:25 mg/kg
Administration:Intraperitoneal injection, for 10 days (days 10–14 and days 17–21)
Result:Prolonged the survival of tumor-burden mice without exhibiting any lethality of mice until day 35.
分子量

534.99

Formula

C32H23ClN2O4

CAS 号

1453835-43-2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.