您好,欢迎来到化工原料网! [登录] [免费注册]
化工原料网
位置:首页 > 产品库 > Levoleucovorin Calcium
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
Levoleucovorin Calcium
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Levoleucovorin Calcium图片
CAS NO:80433-71-2
包装与价格:
包装价格(元)
10 mM * 1 mL in Water电议
100mg电议
500mg电议
1 g电议
2 g电议
5 g电议
10 g电议

产品名称
左亚叶酸钙
Calcium Levofolinate
CL307782
产品介绍
Levoleucovorin Calcium (Calcium levofolinate) 是 Leucovorin Calcium (HY-13664) 的左旋异构体,具有抗肿瘤作用。Levoleucovorin Calcium 也是5-Fluorouracil (HY-90006) 抗癌细胞毒性的增强剂。
生物活性

Levoleucovorin Calcium (Calcium levofolinate), a levo isoform ofLeucovorin Calcium(HY-13664), possesses antineoplastic effects. Levoleucovorin Calcium is also an augmentor of5-fluorouracil(HY-90006) cytotoxicity againstcancer[1][2].

体内研究
(In Vivo)

Levoleucovorin Calcium (6, 20 or 60 mg/kg/day; i.v.; for 4 weeks) enhances the toxicity of5-Fluorouracil[2].

Animal Model:Crj:CD(SD)BR rats (5 weeks)[2]
Dosage:6, 20 or 60 mg/kg/day
Administration:i.v.; for 4 weeks (combined with 10 mg/kg/day5-Fluorouracil)
Result:Decreased the RBC counts, increased extramedullary hematopoiesis and enhanced the suppression of lymphatic organs.
Induced the potentiation in the toxicity of5-Fluorouracilappeared to be mainly immuno-suppression and myelosuppression, which were related to the anti-tumor activity of 5-Fluorouracil.
Clinical Trial
分子量

511.50

性状

Solid

Formula

C20H21CaN7O7

CAS 号

80433-71-2

中文名称

叶酸杂质15

结构分类
  • Ketones, Aldehydes, Acids
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

溶解性数据
In Vitro: 

H2O : 10 mg/mL(19.55 mM;Need ultrasonic)

DMSO :< 1 mg/mL(insoluble or slightly soluble)

配制储备液
浓度溶剂体积质量1 mg5 mg10 mg
1 mM1.9550 mL9.7752 mL19.5503 mL
5 mM0.3910 mL1.9550 mL3.9101 mL
10 mM0.1955 mL0.9775 mL1.9550 mL
*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80℃, 6 months; -20℃, 1 month (sealed storage, away from moisture and light)。-80℃ 储存时,请在 6 个月内使用,-20℃ 储存时,请在 1 个月内使用。