CAS NO: | 2089288-03-7 |
包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
1mg | 电议 |
5mg | 电议 |
10mg | 电议 |
25mg | 电议 |
50mg | 电议 |
100mg | 电议 |
200mg | 电议 |
生物活性 | AZD1390 is a potent, highly selective, orally bioavailable, brain-penetrantATMinhibitor with anIC50of 0.78 nM in cell[1]. | ||||||||||||||||
IC50& Target[1] |
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体内研究 (In Vivo) | Median survival of mice treated with AZD1390 and radiation are significantly longer than untreated control mice (p=0.001). No overt signs of treatment toxicity are observed with small animal radiation research platform (SARRP) contrary to wholehead irradiated mice that seem to develop mucositis and difficulties drinking and eating at doses >10 Gy in combination with AZD1390[2]. | ||||||||||||||||
Clinical Trial | |||||||||||||||||
分子量 | 477.57 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C27H32FN5O2 | ||||||||||||||||
CAS 号 | 2089288-03-7 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 |
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溶解性数据 | In Vitro: DMSO : 25 mg/mL(52.35 mM;Need ultrasonic and warming) 配制储备液
* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 |