包装 | 价格(元) |
100mg | 电议 |
250mg | 电议 |
500mg | 电议 |
生物活性 | ATR-IN-20 is a potentATR(ATM/ATR) inhibitor with anIC50of 3 nM. ATR-IN-20 possess an inhibitory effect onmTOR(IC50of 18 nM) while displaying good selectivity againstPI3Kα(100 nM),ATM(100 nM), andDNA-PK(662 nM). ATR-IN-20 exhibits excellent pharmacokinetic profile (F = 30%), and has anticancer effects[1]. | ||||||||
IC50& Target[1] |
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体外研究 (In Vitro) | ATR-IN-20 (化合物 48f;0.03-3 μM;24 小时) 在 LoVo 细胞中以浓度依赖性方式显着抑制迁移[1]。 Cell Migration Assay[1]
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体内研究 (In Vivo) | ATR-IN-20(化合物 48f)显示出良好的药代动力学特征,在 SD 大鼠中的生物利用度为 30.0%、可接受的血浆蛋白结合 (PPB)、高渗透性和低药物-药物相互作用风险[1]< /sup>。 | ||||||||
分子量 | 545.65 | ||||||||
Formula | C29H31N5O4S | ||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||
储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |