CAS NO: | 1233339-22-4 |
包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
5mg | 电议 |
10mg | 电议 |
50mg | 电议 |
100mg | 电议 |
200mg | 电议 |
500mg | 电议 |
生物活性 | AZ20 is a potent and selective inhibitor ofATRwith anIC50of 5 nM, and has 8-fold selectivity againstmTOR(IC50=38 nM). | ||||||||||||||||
IC50& Target[1] |
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体外研究 (In Vitro) | AZ20 inhibits ATR immunoprecipitated from HeLa nuclear extracts with an IC50of 5 nM and ATR mediated phosphorylation of Chk1 in HT29 colorectal adenocarcinoma tumor cells with an IC50of 50 nM[1]. | ||||||||||||||||
体内研究 (In Vivo) | AZ20 (25, 50 mg/kg, p.o.) has high permeability combined with good stability to rat hepatocytes and, despite the lack of progress in achieving markedly higher solubility, has respectable bioavailability in a low dose rat PK study. AZ20 (25, 50 mg/kg, p.o.) leads to significant tumor growth inhibition in female nude mice bearing LoVo tumors[1]. | ||||||||||||||||
分子量 | 412.51 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C21H24N4O3S | ||||||||||||||||
CAS 号 | 1233339-22-4 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 |
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溶解性数据 | In Vitro: DMSO : ≥ 100 mg/mL(242.42 mM) *"≥" means soluble, but saturation unknown. 配制储备液
* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo: 请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照In Vitro方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用;
以下溶剂前显示的百
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