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Reversine
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Reversine图片
CAS NO:656820-32-5
包装与价格:
包装价格(元)
10 mM * 1 mL in DMSO电议
5mg电议
10mg电议
50mg电议
100mg电议
200mg电议
500mg电议

产品名称
逆转素
产品介绍
Reversine 是一种ATP-竞争性的Aurora kinase抑制剂,作用于Aurora AAurora BAurora CIC50分别为 400,500 和 400 nM。
生物活性

Reversine is a novel class of ATP-competitiveAurora kinaseinhibitor withIC50s of 400, 500 and 400 nM forAurora A,Aurora BandAurora C, respectively.

IC50& Target[1]

Aurora A

400 nM (IC50)

Aurora B

500 nM (IC50)

Aurora C

400 nM (IC50)

体外研究
(In Vitro)

Reversine, a novel Aurora kinases inhibitor, inhibits colony formation of human acute myeloid leukemia cells. Reversine is a potent inhibitor of Aurora A and B and is also an inhibitor of Aurora C kinase. Aurora A and B activities are inhibited by 80% and Aurora kinase C by 55%, already at a concentration of 0.5 μM, whereas no inhibition or only modest inhibition is observed on others kinases tested. In a second round of experiments, the IC50of Reversine is determined on Aurora kinase A to be 400 nM, whereas Aurora kinase B and C IC50are 500 and 400 nM, respectively. The IC50is also determined on MEK1 is >1.5 μM and that the IC50on muscle myosin (an analogue of nonmuscle myosin II) is 350 nM[1].

体内研究
(In Vivo)

The combination of Reversine and aspirin can more efficiently induce cell cycle arrest and apoptosis. To evaluate the anti-tumor effect of this combination, a xenograft nude mouse model is established by s.c. injection. Mice inoculated with cervical cancer cells have lost about 10 % of their initial body weight by about 16 days after tumor inoculation. However, tumor growth (tumor weight) is reduced and the mice survive longer in the combination group[2].

分子量

393.49

性状

Solid

Formula

C21H27N7O

CAS 号

656820-32-5

中文名称

逆转素

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder-20°C3 years
4°C2 years
In solvent-80°C6 months
-20°C1 month
溶解性数据
In Vitro: 

DMSO : 20 mg/mL(50.83 mM;Need ultrasonic)

配制储备液
浓度溶剂体积质量1 mg5 mg10 mg
1 mM2.5414 mL12.7068 mL25.4136 mL
5 mM0.5083 mL2.5414 mL5.0827 mL
10 mM0.2541 mL1.2707 mL2.5414 mL
*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80℃, 6 months; -20℃, 1 month。-80℃ 储存时,请在 6 个月内使用,-20℃ 储存时,请在 1 个月内使用。