CAS NO: | 656820-32-5 |
包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
5mg | 电议 |
10mg | 电议 |
50mg | 电议 |
100mg | 电议 |
200mg | 电议 |
500mg | 电议 |
生物活性 | Reversine is a novel class of ATP-competitiveAurora kinaseinhibitor withIC50s of 400, 500 and 400 nM forAurora A,Aurora BandAurora C, respectively. | ||||||||||||||||
IC50& Target[1] |
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体外研究 (In Vitro) | Reversine, a novel Aurora kinases inhibitor, inhibits colony formation of human acute myeloid leukemia cells. Reversine is a potent inhibitor of Aurora A and B and is also an inhibitor of Aurora C kinase. Aurora A and B activities are inhibited by 80% and Aurora kinase C by 55%, already at a concentration of 0.5 μM, whereas no inhibition or only modest inhibition is observed on others kinases tested. In a second round of experiments, the IC50of Reversine is determined on Aurora kinase A to be 400 nM, whereas Aurora kinase B and C IC50are 500 and 400 nM, respectively. The IC50is also determined on MEK1 is >1.5 μM and that the IC50on muscle myosin (an analogue of nonmuscle myosin II) is 350 nM[1]. | ||||||||||||||||
体内研究 (In Vivo) | The combination of Reversine and aspirin can more efficiently induce cell cycle arrest and apoptosis. To evaluate the anti-tumor effect of this combination, a xenograft nude mouse model is established by s.c. injection. Mice inoculated with cervical cancer cells have lost about 10 % of their initial body weight by about 16 days after tumor inoculation. However, tumor growth (tumor weight) is reduced and the mice survive longer in the combination group[2]. | ||||||||||||||||
分子量 | 393.49 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C21H27N7O | ||||||||||||||||
CAS 号 | 656820-32-5 | ||||||||||||||||
中文名称 | 逆转素 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 |
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溶解性数据 | In Vitro: DMSO : 20 mg/mL(50.83 mM;Need ultrasonic) 配制储备液
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