L-838,417 是 GABAA 受体的 α2、α3 和 α5 亚型的选择性部分激动剂和 α1 的拮抗剂，结合 Ki 值为 0.79 nM、0.67 nM、1.67 nM、267 nM、2.25 nM 和 2183 nM α1β3γ2、α2β3γ2、α3β3γ2、α4β3γ2、α5β3γ2和α6β3γ2。
| Cas No. | 286456-42-6 |
| 别名 | 3-(2,5-二氟苯基)-7-(1,1-二甲基乙基)-6-[(1-甲基-1H-1,2,4-,三唑-5-基)甲氧基]-1,2,4-4-三唑[4,3-B]哒嗪 |
| 化学名 | 7-(tert-butyl)-3-(2,5-difluorophenyl)-6-((1-methyl-1H-1,2,4-triazol-5-yl)methoxy)-[1,2,4]triazolo[4,3-b]pyridazine |
| Canonical SMILES | FC(C(C1=NN=C2N1N=C(C(C(C)(C)C)=C2)OCC3=NC=NN3C)=C4)=CC=C4F |
| 分子式 | C19H19F2N7O |
| 分子量 | 399.4 |
| 溶解度 | <7.99mg/ml in ethanol;<19.97mg/ml in DMSO |
| 储存条件 | Store at -20℃ |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
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