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Ellagic acid
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Ellagic acid图片
CAS NO:476-66-4
包装与价格:
包装价格(元)
500mg电议
1 g电议
5 g电议
10 g电议
50 g电议

产品名称
鞣花酸
产品介绍
Ellagic acid 是一种天然的抗氧化剂,为有效的,ATP 竞争性的CK2抑制剂,IC50Ki值分别为 40 nM 和 20 nM。
生物活性

Ellagic acid is a natural antioxidant, and acts as a potent and ATP-competitiveCK2inhibitor, with anIC50of 40 nM and aKiof 20 nM.

IC50& Target[1]

CK2

40 nM (IC50)

体外研究
(In Vitro)

Ellagic acid is a potent CK2 inhibitor, with an IC50of 40 nM and a Kiof 20 nM. Ellagic acid also blocks other kinases such as LYN, PKA, SYK, GSK3, FGR and CK1, with IC50s of 2.9, 3.5, 4.3, 7.5, 9.4 and 13.0 μM, respectively, and shows no obvious effects on DYRK1a, CSK, NPM-ALK, RET and FLT3 (IC50s >40 μM). Ellagic acid (5-100 μM) shows inhibitory activities against Karpas299, SUDHL1, SR786, and FE-PD cell lines[1]. Ellagic acid (10 μM) exhibits cytotoxic effects on MCF-7 cells after treatment of radiation. Ellagic acid (10 μM) in combination with Irradiation (IR) significantly abridges the capacity of MCF-7 cells to form colonies equated with individual treatments. Ellagic acid with IR also induces cell apoptosis, and facilitates the upregulation of pro-apopttotic Bax and downregulation of Bcl-2 in MCF-7 cells[3].

体内研究
(In Vivo)

Ellagic acid (EA; 10 mg/kg/day; p.o., 14 days) strongly decreases MDA brain content by 17%, and reduces the levels of brain TNF-α by 42% in rats. Ellagic acid markedly increases the reduced brain contents of 5-HT (39%), dopamine (DA, 71%), and norepinephrine (NE, 77%). Ellagic acid (10 mg/kg, p.o., 14 days) causes decreased histopathological changes induced by Doxorubicin in rats[2].

Clinical Trial
分子量

302.19

性状

Solid

Formula

C14H6O8

CAS 号

476-66-4

中文名称

鞣花酸

结构分类
  • Phenols
  • Polyphenols
来源
  • Plants
  • other families
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder-20°C3 years
4°C2 years
In solvent-80°C6 months
-20°C1 month
溶解性数据
In Vitro: 

DMSO : ≥ 2.5 mg/mL(8.27 mM)

Ethanol :< 1 mg/mL(insoluble)

H2O :< 0.1 mg/mL(insoluble)

*"≥" means soluble, but saturation unknown.

配制储备液
浓度溶剂体积质量1 mg5 mg10 mg
1 mM3.3092 mL16.5459 mL33.0918 mL
5 mM0.6618 mL3.3092 mL6.6184 mL
10 mM---------
*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80℃, 6 months; -20℃, 1 month。-80℃ 储存时,请在 6 个月内使用,-20℃ 储存时,请在 1 个月内使用。